Faculty of Medicine, Department of Microbiology and Molecular Medicine, University of Geneva, Genève, Switzerland.
Methods Mol Biol. 2021;2209:17-34. doi: 10.1007/978-1-0716-0935-4_2.
RNA helicases are ubiquitous, highly conserved RNA-binding enzymes that use the energy derived from the hydrolysis of nucleoside triphosphate to modify the structure of RNA molecules and/or the functionality of ribonucleoprotein complexes. Ultimately, the action of RNA helicases results in changes in gene expression that allow the cell to perform crucial functions. In this chapter, we review established and emerging concepts for DEAD-box and DExH-box RNA helicases. We mention examples from both eukaryotic and prokaryotic systems, in order to highlight common themes and specific actions.
RNA 解旋酶是普遍存在的、高度保守的 RNA 结合酶，它们利用核苷三磷酸水解产生的能量来改变 RNA 分子的结构和/或核糖核蛋白复合物的功能。最终，RNA 解旋酶的作用导致基因表达的变化，使细胞能够执行关键功能。在本章中，我们回顾了 DEAD-box 和 DExH-box RNA 解旋酶的既定和新兴概念。我们提到了来自真核和原核系统的例子，以突出共同的主题和特定的作用。
