CAMAG DBS Laboratory, Muttenz, Switzerland.
Drug Test Anal. 2021 Jan;13(1):69-73. doi: 10.1002/dta.2977. Epub 2020 Nov 22.
The perspective discusses quantitative DBS analysis for anti-doping testing in an athletic population and why only using volumetric sampling for this subgroup might not be enough. It presents examples to highlight where HCT variations occur, followed by a whole blood to plasma ratio and an HCT extraction bias discussion. Finally, options to correct for the HCT bias are presented.
本文从不同角度探讨了竞技人群中 DBS 定量分析用于反兴奋剂检测的问题，以及为什么仅对这一亚组使用容量采样可能还不够。本文举例说明了 HCT 变化发生的情况，接着讨论了全血到血浆的比值和 HCT 提取偏倚问题，最后提出了纠正 HCT 偏倚的方法。
