Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai University of Finance and Economics, Shanghai, China.
Endokrynol Pol. 2020;71(5):432-440. doi: 10.5603/EP.a2020.0064.
Hypoxia-inducible factors (HIFs), as a family of transcription factors involved in the cellular response to hypoxia, are key regulatory factors in the regulation mechanism of an organism's response to hypoxia. A large number of studies have shown that HIFs are closely related to the angiogenesis, erythropoiesis, cell metabolism, and autophagy of organisms, as well as the occurrence and development of tumours. Therefore, it is of great significance to further study HIFs to understand and treat tumours or other related diseases. This paper summarises the structure, oxygen-dependent degradation mechanism, non-oxygen-dependent degradation mechanism, transcriptional activation mechanism, relevant signalling pathways, and inhibitors of HIFs, in order to provide new clues for the treatment of tumour, vascular, and other related diseases.
缺氧诱导因子（HIFs）作为参与细胞对缺氧反应的转录因子家族，是调节机体对缺氧反应的调控机制中的关键调节因子。大量研究表明，HIFs 与生物体的血管生成、红细胞生成、细胞代谢和自噬以及肿瘤的发生和发展密切相关。因此，进一步研究 HIFs 对于理解和治疗肿瘤或其他相关疾病具有重要意义。本文总结了 HIFs 的结构、氧依赖性降解机制、非氧依赖性降解机制、转录激活机制、相关信号通路和抑制剂，为肿瘤、血管等相关疾病的治疗提供新的线索。
