Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China.
J Int Med Res. 2020 Nov;48(11):300060520965398. doi: 10.1177/0300060520965398.
We herein describe the preoperative and postoperative clinical data of a patient with a rare case of vulvar malignant melanoma and discuss her clinical characteristics and prognosis. After surgical resection and immunotherapy, the patient's illness continued to worsen. She then received local vulvar radiotherapy. However, further treatment was discontinued because of intolerable complications of radiotherapy, and the patient died about 18 months postoperatively. Management of vulvar malignant melanoma is challenging. No unified, effective, and standardized diagnostic and treatment plan has been established for this disease. Surgery remains the primary treatment modality for locally resectable vulvar malignant melanoma. Radiation therapy and chemotherapy do not benefit survival. Encouragingly, however, immunotherapy and targeted therapy have shown clinical efficacy in metastatic vulvar malignant melanoma.
我们在此描述了一例外阴恶性黑色素瘤罕见病例的术前和术后临床资料，并讨论了其临床特点和预后。患者接受了手术切除和免疫治疗，但病情持续恶化。随后，她接受了局部外阴放疗。然而，由于放疗的不可耐受的并发症，进一步的治疗被停止，患者术后约 18 个月死亡。外阴恶性黑色素瘤的治疗具有挑战性。对于这种疾病，尚未建立统一、有效和标准化的诊断和治疗方案。手术仍然是局部可切除外阴恶性黑色素瘤的主要治疗方式。放疗和化疗对生存无益。然而，令人鼓舞的是，免疫治疗和靶向治疗在外阴恶性黑色素瘤的转移中显示出了临床疗效。
