Liang Jia-Quan, Liao Hai-Rong, Xu Cai-Xia, Li Xiao-Ling, Wei Ze-Xu, Xie Guo-Jun, Cheng Yong
Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, People's Republic of China.
Center on Translational Neuroscience, Minzu University of China, Beijing, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Nov 10;16:2689-2693. doi: 10.2147/NDT.S277392. eCollection 2020.
MicroRNAs (miRs) have been suggested to be biomarkers to inform the diagnosis of major depressive disorder (MDD). We have previously shown that exosome-derived miR-139-5p had potential in differentiating between patients with MDD and healthy control (HC) subjects.
To validate the potential of exosome-derived miR-139-5p as a biomarker for MDD, here we recruited 30 patients with MDD and 30 HC subjects, and used TaqMan probes to detect serum exosomal miR-139-5p levels.
The data showed that patients with MDD had significantly increased exosomal miR-139-5p levels when compared with controls. Correlation analysis suggested that sex, age, and body mass index did not significantly affect blood exosomal miR-139-5p levels in the tested subjects. The ROC curve showed that serum-derived miR-139-5p had reasonable performance in discriminating patients with MDD and HC subjects, with a sensitivity of 0.867 and specificity of 0.767, and the AUC was 0.807.
Taken together, these results demonstrated that patients with MDD were accompanied by significantly increased blood exosomal miR-139-5p levels, and exosomal miR-139-5p is a promising biomarker for the diagnosis of MDD.
微小RNA（miRs）被认为是用于指导重度抑郁症（MDD）诊断的生物标志物。我们之前已经表明，外泌体来源的miR-139-5p在区分MDD患者和健康对照（HC）受试者方面具有潜力。
为了验证外泌体来源的miR-139-5p作为MDD生物标志物的潜力，我们招募了30例MDD患者和30名HC受试者，并使用TaqMan探针检测血清外泌体miR-139-5p水平。
数据显示，与对照组相比，MDD患者的外泌体miR-139-5p水平显著升高。相关性分析表明，性别、年龄和体重指数对受试对象血液外泌体miR-139-5p水平没有显著影响。ROC曲线显示，血清来源的miR-139-5p在区分MDD患者和HC受试者方面具有合理的性能，灵敏度为0.867，特异性为0.767，曲线下面积为0.807。
综上所述，这些结果表明，MDD患者血液外泌体miR-139-5p水平显著升高，外泌体miR-139-5p是一种有前景的MDD诊断生物标志物。
