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基于免疫信息学设计抗铜绿假单胞菌果糖二磷酸醛缩酶蛋白的表位肽疫苗。

Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics.

机构信息

Faculty of Medicine, University of Seychelles-American Institute of Medicine, Seychelles.

Department of Pharmacies, National Medical Supplies Fund, Sudan.

出版信息

J Immunol Res. 2020 Nov 5;2020:9475058. doi: 10.1155/2020/9475058. eCollection 2020.

DOI:10.1155/2020/9475058
PMID:33204735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7666636/
Abstract

is a common pathogen that is responsible for serious hospital-acquired infections, ventilator-associated pneumonia, and various sepsis syndromes. Also, it is a multidrug-resistant pathogen recognized for its ubiquity and its intrinsically advanced antibiotic-resistant mechanisms. It usually affects immunocompromised individuals but can also infect immunocompetent individuals. There is no vaccine against it available till now. This study predicts an effective epitope-based vaccine against fructose bisphosphate aldolase (FBA) of using immunoinformatics tools. The protein sequences were obtained from NCBI, and prediction tests were undertaken to analyze possible epitopes for B and T cells. Three B cell epitopes passed the antigenicity, accessibility, and hydrophilicity tests. Six MHC I epitopes were found to be promising, while four MHC II epitopes were found promising from the result set. Nineteen epitopes were shared between MHC I and II results. For the population coverage, the epitopes covered 95.62% worldwide excluding certain MHC II alleles. We recommend and studies to prove its effectiveness.

摘要

是一种常见的病原体，可导致严重的医院获得性感染、呼吸机相关性肺炎和各种败血症综合征。此外，它还是一种多药耐药病原体，具有普遍性和内在先进的抗生素耐药机制。它通常影响免疫功能低下的个体，但也可以感染免疫功能正常的个体。目前还没有针对它的疫苗。本研究使用免疫信息学工具预测了一种针对果糖-1,6-二磷酸醛缩酶（FBA）的有效基于表位的疫苗。从 NCBI 获得蛋白质序列，并进行预测测试以分析 B 细胞和 T 细胞的可能表位。三个 B 细胞表位通过了抗原性、可及性和亲水性测试。发现六个 MHC I 表位有希望，而从结果集中发现四个 MHC II 表位有希望。19 个表位在 MHC I 和 II 结果之间共享。对于人群覆盖率，表位覆盖了全球 95.62%的人口，不包括某些 MHC II 等位基因。我们建议进行 和 研究以证明其有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/2f0a52fc471f/JIR2020-9475058.012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/998708d603a0/JIR2020-9475058.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/47724b669aac/JIR2020-9475058.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/f60ee5993082/JIR2020-9475058.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/b82ad5f0237f/JIR2020-9475058.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/47a014f09972/JIR2020-9475058.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/b673cefe859a/JIR2020-9475058.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/9073fa94d294/JIR2020-9475058.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/1464171d3831/JIR2020-9475058.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/a19ea2372f3a/JIR2020-9475058.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/53cd57ad8456/JIR2020-9475058.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/2abf5183b973/JIR2020-9475058.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/2f0a52fc471f/JIR2020-9475058.012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/998708d603a0/JIR2020-9475058.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/47724b669aac/JIR2020-9475058.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/f60ee5993082/JIR2020-9475058.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/b82ad5f0237f/JIR2020-9475058.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/47a014f09972/JIR2020-9475058.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/b673cefe859a/JIR2020-9475058.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/9073fa94d294/JIR2020-9475058.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/1464171d3831/JIR2020-9475058.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/a19ea2372f3a/JIR2020-9475058.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/53cd57ad8456/JIR2020-9475058.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/2abf5183b973/JIR2020-9475058.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7682/7666636/2f0a52fc471f/JIR2020-9475058.012.jpg

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