Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
J Clin Endocrinol Metab. 2021 Mar 8;106(3):858-871. doi: 10.1210/clinem/dgaa848.
Despite the gut microbiome being widely studied in metabolic diseases, its role in polycystic ovary syndrome (PCOS) has been scarcely investigated.
Compare the gut microbiome in late fertile age women with and without PCOS and investigate whether changes in the gut microbiome correlate with PCOS-related metabolic parameters.
Prospective, case-control study using the Northern Finland Birth Cohort 1966.
General community.
A total of 102 PCOS women and 201 age- and body mass index (BMI)-matched non-PCOS control women. Clinical and biochemical characteristics of the participants were assessed at ages 31 and 46 and analyzed in the context of gut microbiome data at the age of 46.
(s): None.
MAIN OUTCOME MEASURE(S): Bacterial diversity, relative abundance, and correlations with PCOS-related metabolic measures.
Bacterial diversity indices did not differ significantly between PCOS and controls (Shannon diversity P = .979, unweighted UniFrac P = .175). Four genera whose balance helps to differentiate between PCOS and non-PCOS were identified. In the whole cohort, the abundance of 2 genera from Clostridiales, Ruminococcaceae UCG-002, and Clostridiales Family XIII AD3011 group, were correlated with several PCOS-related markers. Prediabetic PCOS women had significantly lower alpha diversity (Shannon diversity P = .018) and markedly increased abundance of genus Dorea (false discovery rate = 0.03) compared with women with normal glucose tolerance.
PCOS and non-PCOS women at late fertile age with similar BMI do not significantly differ in their gut microbial profiles. However, there are significant microbial changes in PCOS individuals depending on their metabolic health.
尽管肠道微生物群在代谢性疾病中得到了广泛的研究，但在多囊卵巢综合征（PCOS）中的作用却鲜有研究。
比较晚生育期有和无 PCOS 的女性的肠道微生物组，并探讨肠道微生物组的变化是否与 PCOS 相关的代谢参数相关。
前瞻性病例对照研究，使用 1966 年芬兰北部出生队列。
一般社区。
共纳入 102 名 PCOS 女性和 201 名年龄和体重指数（BMI）匹配的非 PCOS 对照组女性。在 31 岁和 46 岁时评估参与者的临床和生化特征，并在 46 岁时进行肠道微生物组数据分析。
无。
细菌多样性、相对丰度以及与 PCOS 相关代谢指标的相关性。
PCOS 组和对照组的细菌多样性指数无显著差异（Shannon 多样性 P =.979，非加权 UniFrac P =.175）。确定了 4 个有助于区分 PCOS 和非 PCOS 的细菌属。在整个队列中，2 个属于梭状芽胞杆菌科的属，即 Ruminococcaceae UCG-002 和梭状芽胞杆菌科第十三家族 AD3011 组的丰度与几种 PCOS 相关标志物相关。与糖耐量正常的女性相比，有前驱糖尿病的 PCOS 女性的 alpha 多样性明显降低（Shannon 多样性 P =.018），且属 Dorea 的丰度显著增加（假发现率 = 0.03）。
晚生育期 BMI 相似的 PCOS 和非 PCOS 女性的肠道微生物群谱无显著差异。然而，根据代谢健康状况，PCOS 个体存在显著的微生物变化。
