Department of Physics, Jadavpur University, Kolkata, India.
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, India.
J Microencapsul. 2021 Jan;38(1):36-46. doi: 10.1080/02652048.2020.1842529. Epub 2020 Nov 30.
To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic acid and poly (d,l-lactide--glycolic) acid (PLGA) for the delivery of docetaxel (DTX) specifically to breast cancer cells.
The CF-NP were synthesised by hydrothermal method and conjugated with DTX in a PLGA matrix and were systematically characterised using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied.
The CF-NP showed good crystallinity with an average particle size of 21 nm and ferromagnetic nature. The DTX-loaded CF-NP (DCF-NP) showed 8.4% (w/w) drug loading with 81.8% loading efficiency with a sustained DTX release over time. An effective internalisation and anti-proliferative efficiency was observed in MCF-7 and MDA-MB-231 breast cancer cells and negligible haemolytic effect.
The DCF-NP can have the potential for the effective delivery of DTX for breast cancer treatment.
使用油酸和聚（丙交酯-乙交酯）（PLGA）开发一种生物相容性的钴铁氧体（CF-NP）纳米药物制剂，用于将多西他赛（DTX）特异性递送至乳腺癌细胞。
通过水热法合成 CF-NP，并在 PLGA 基质中与 DTX 缀合，使用 XRD、FE-SEM、TEM、DLS、FTIR、TGA、SQUID 等进行系统表征。评估了载药、体外药物释放、细胞摄取、细胞毒性和溶血作用。
CF-NP 具有良好的结晶度，平均粒径为 21nm，具有铁磁性。载多西他赛的 CF-NP（DCF-NP）的载药量为 8.4%（w/w），载药效率为 81.8%，随着时间的推移，DTX 释放呈持续释放。在 MCF-7 和 MDA-MB-231 乳腺癌细胞中观察到有效的内化和抗增殖效率，且溶血作用可忽略不计。
DCF-NP 有可能有效递送至乳腺癌治疗的 DTX。
