[Plastipore prosthesis in the animal experiment].

The goal of this study was to evaluate histologically the tissue response to Plastipore implants in the middle ear of guinea pigs three months after implantation. The histologic response to the Plastipore implants showed a fibrous capsule formation covered by an epithelial sheet already after one week. Fibrous tissue of the capsule infiltrated larger surface pores. Multinuclear giant cells and macrophages were the predominant cell types in the porosity of the Plastipore implants. There was no clear evidence of breakdown of the prostheses. Plastipore elicits a focal foreign body phagocytic response and shows a limited biocompatibility.