Li Meijie, Xia Qingqing, Zhang Haibo, Zhang Rubing, Yang Jianming
Energy-Rich Compound Production by Photosynthetic Carbon Fixation Research Center, Shandong Key Laboratory of Applied Mycology, College of Life Sciences, Qingdao Agricultural University, 700 Changchen Road, Qingdao, Shandong 266109, People's Republic of China.
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 135 Songling Road, Qingdao, Shandong 266101, People's Republic of China.
J Agric Food Chem. 2020 Nov 18. doi: 10.1021/acs.jafc.0c06020.
As a result of the extensive use of lycopene in a variety of fields, especially the dietary supplement and health food industries, the production of lycopene has attracted considerable interest. Lycopene can be obtained through extraction from vegetables and chemical synthesis. Alternatively, the microbial production of lycopene has been extensively researched in recent years. Various types of microbial hosts have been evaluated for their potential to accumulate a high level of lycopene. Metabolic engineering of the hosts and optimization of culture conditions are performed to enhance lycopene production. After years of research, great progress has been made in lycopene production. In this review, strategies used to improve lycopene production in different microbial hosts and the advantages and disadvantages of each microbial host are summarized. In addition, future perspectives of lycopene production in different microbial hosts are discussed.
由于番茄红素在各种领域的广泛应用，尤其是在膳食补充剂和保健食品行业，番茄红素的生产引起了相当大的关注。番茄红素可以通过从蔬菜中提取和化学合成获得。另外，近年来番茄红素的微生物生产也得到了广泛研究。人们评估了各种类型的微生物宿主积累高水平番茄红素的潜力。对宿主进行代谢工程改造并优化培养条件以提高番茄红素的产量。经过多年研究，番茄红素生产取得了巨大进展。在本综述中，总结了用于提高不同微生物宿主中番茄红素产量的策略以及每种微生物宿主的优缺点。此外，还讨论了不同微生物宿主中番茄红素生产的未来前景。
