Miura S, Jimbo M, Sasaki T, Oguma S, Sasaki Y, Okazaki H, Taguchi Y
Second Department of Surgery, School of Medicine, Tohoku University, Sendai, Japan.
Nihon Geka Gakkai Zasshi. 1987 Aug;88(8):982-90.
To determine the utility of injection of polymers to obliterate the pancreatic duct, we examined this method and others viz, pancreatico-duodenostomy, duct ligation, and the open duct method. We performed the pancreatic duct treatment on the left portion of the pancreas in dogs without any transplantation. The right portion of the pancreas was removed. We used Neoprene and Ethibloc as injected materials. One month after the operation, the polymer injected dogs showed the same endocrine function as the duct ligated and open duct ones. However, three months after the operation, endocrine function of the polymer injected dogs improved and was better than that of the other two groups which showed no changes. The endocrine function of the polymer injected dogs had remained stable for one year and was close to that of the optimal function of pancreatico-duodenostomy. Furthermore, after operation in the polymer injected dogs, the elevated serum amylase descended to normal level. This occurred much less rapidly in the other groups. The fibrosis of the polymer injected dogs' pancreas was completed by 3 months, while the dogs in the other groups still had some degenerated exocrine tissues. Rapid destruction of exocrine tissues, induced by the injection of the polymer, appears to encourage reconstruction of endocrine tissue.
为了确定注射聚合物闭塞胰管的效用，我们研究了这种方法以及其他方法，即胰十二指肠吻合术、导管结扎术和开放导管法。我们在未进行任何移植的狗的胰腺左侧部分进行了胰管治疗。切除了胰腺的右侧部分。我们使用氯丁橡胶和乙基纤维素作为注射材料。术后1个月，注射聚合物的狗与导管结扎和开放导管的狗具有相同的内分泌功能。然而，术后3个月，注射聚合物的狗的内分泌功能有所改善，且优于其他两组无变化的狗。注射聚合物的狗的内分泌功能在1年内保持稳定，接近胰十二指肠吻合术的最佳功能。此外，注射聚合物的狗术后血清淀粉酶升高降至正常水平。其他组这种情况发生得没有那么快。注射聚合物的狗的胰腺纤维化在3个月时完成，而其他组的狗仍有一些退化的外分泌组织。聚合物注射引起的外分泌组织的快速破坏似乎促进了内分泌组织的重建。
