Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.
Institute of Earth Systems, Division of Rural Sciences and Food Systems, University of Malta, Msida, Malta.
J Matern Fetal Neonatal Med. 2022 Nov;35(22):4365-4369. doi: 10.1080/14767058.2020.1849120. Epub 2020 Nov 18.
Coffee intake is common during pregnancy. However, the influence of coffee and caffeine on pregnancy has not yet been fully determined. Some studies show that high coffee intake could cause miscarriage, preterm birth or reduction of fetal growth, but other studies do not support these findings. The aim of the present study was to analyze data collected from a database focusing on coffee intake during pregnancy, which was specifically created for multicenter studies carried out in the maternity units of Italian general hospitals. Principal outcomes of pregnancy during pregnancy were considered. Data of 5405 pregnancies were collected by a direct questionnaire supplemented with data from patients'clinical records during the survey named PHYTO.VIG.GEST. We observed that 42.3% of the total sample had consumed at least one coffee a day during pregnancy. Analysis of a dose-response relationship showed that, in pregnant women starting from the consumption of three coffees a day (6% of pregnant women consuming coffee), there is a statistically significant association between number of coffees and reduction of babies birth weight (< 2500 g). Even though high coffee intake is known to influence negatively birth weight, our results indicate that a significant percentage of pregnant women maintain this habit.
孕期喝咖啡很常见。然而，咖啡和咖啡因对妊娠的影响尚未完全确定。一些研究表明，大量摄入咖啡可能会导致流产、早产或胎儿生长减少，但其他研究并不支持这些发现。本研究的目的是分析专门为意大利综合医院产科单位进行的多中心研究而创建的数据库中收集的关于孕期咖啡摄入量的数据。主要的妊娠结局被认为是怀孕。通过直接问卷调查收集了 5405 例妊娠的数据，并在名为 PHYTO.VIG.GEST 的调查中补充了患者临床记录的数据。我们观察到，总样本中有 42.3%的人在孕期至少每天喝一杯咖啡。剂量反应关系分析表明，在每天饮用三杯咖啡的孕妇（6%的孕妇喝咖啡）中，咖啡摄入量与婴儿出生体重减少（<2500g）之间存在统计学显著关联。尽管高咖啡摄入量已知会对出生体重产生负面影响，但我们的结果表明，相当比例的孕妇仍保持这种习惯。
