Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Infect Disord Drug Targets. 2021;21(5):e270421188119. doi: 10.2174/1871526520666201117145733.
In recent years, more attention has been focused in the practice of both crude extract of medicinal plants, and the screening plant-derived compounds as substitute scolicidal agents during hydatid cyst surgery. The present study was designed to review the protoscolicidal effects of some Iranian herbal medicines against hydatid cyst protoscoleces.
English databases, including PubMed, Google Scholar, Web of Science, EBSCO, Science Direct, and Scopus were searched for publications worldwide related to protoscolicidal effects of Iranian herbal medicines without date limitation so that identify all published articles (in vitro, in vivo, clinical and case-control) have studied. Keywords included "Protoscolicidal", "Scolicidal", "Herbal medicines", "Extract", "Essential oil", "Plant", "In vitro", and "Iran". Moreover, the language of data collection was limited to English.
In total, 40 papers up to 2020 were included in the present systematic review. The most studies were conducted on protoscolicidal activity of methanolic extracts (17 studies) followed by essential oils (15 studies), and aqueous extract (3 studies). The most commonly used part of herbs were leaves (21 herbs), seeds (8 herbs), and fruit (6 herbs), respectively. Moreover, the most prevalent herbal family was Lamiaceae (6 studies), followed by Apiaceae (5 studies) and Liliaceae (5 studies).
Considering the high efficacy of Iranian herbal medicines against hydatid cyst protoscoleces, it can be concluded that Iranian herbal medicines have ability to consider as new alternative protoscolicidal agents during hydatid cyst surgery; however, more clinical studies are required to discover the precise protoscolicida activity of Iranian medicines in animal and human subjects.
近年来，人们越来越关注药用植物粗提取物的应用，以及筛选植物源性化合物作为包虫囊肿手术中替代杀原虫剂。本研究旨在综述一些伊朗草药对包虫囊肿原头节的原头节杀伤作用。
在全球范围内，通过英语数据库，包括 PubMed、Google Scholar、Web of Science、EBSCO、Science Direct 和 Scopus，无时间限制地搜索有关伊朗草药对原头节杀伤作用的出版物，以确定所有已发表的文章（体外、体内、临床和病例对照）。关键词包括“原头节杀伤”、“杀原虫”、“草药”、“提取物”、“精油”、“植物”、“体外”和“伊朗”。此外，数据收集的语言仅限于英语。
总共纳入了 40 篇截至 2020 年的研究。大多数研究是关于甲醇提取物（17 项研究）、精油（15 项研究）和水提物（3 项研究）对原头节杀伤活性的研究。草药最常用的部分是叶（21 种草药）、种子（8 种草药）和果实（6 种草药）。此外，最常见的草药科是唇形科（6 项研究），其次是伞形科（5 项研究）和百合科（5 项研究）。
考虑到伊朗草药对包虫囊肿原头节有很高的疗效，可以得出结论，伊朗草药有能力在包虫囊肿手术中作为新的替代原头节杀伤剂；然而，需要更多的临床研究来发现伊朗药物在动物和人体中的精确原头节杀伤活性。
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