剖宫产与偏头痛的关联：一项基于登记册的回顾性HUNT人群队列研究
Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study.
作者信息
Kristoffersen Espen Saxhaug, Børte Sigrid, Hagen Knut, Zwart John-Anker, Winsvold Bendik Slagsvold
机构信息
Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway
Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
出版信息
BMJ Open. 2020 Nov 18;10(11):e040685. doi: 10.1136/bmjopen-2020-040685.
OBJECTIVES
To evaluate the association between caesarean section and migraine in a population-based register-linked cohort study.
SETTING
Data from the population-based Nord-Trøndelag Health Studies (HUNT2 and HUNT3) were linked to information from the Norwegian Medical Birth Registry.
PARTICIPANTS
65 343 participants responded to the headache questions in any of the two HUNT studies. Only those answering the headache questions in HUNT2 or 3 and had information about mode of delivery in the Norwegian Medical Birth Registry (born after 1967) were included. Our final sample consisted of 6592 women and 4602 men, aged 19-41 years.
OUTCOMES
ORs for migraine given caesarean section. Analyses were performed in multivariate logistic regression models.
RESULTS
After adjusting for sex, age and fetal growth restriction, delivery by caesarean section was not associated with migraine later in life (OR 0.86, 95% CI 0.64 to 1.15). Delivery by caesarean section was associated with a reduced OR of non-migrainous headache (OR 0.77, 95% CI 0.60 to 0.99).
CONCLUSION
No association was found between caesarean section and migraine in this population-based register-linked study.
目的
在一项基于人群的登记关联队列研究中评估剖宫产与偏头痛之间的关联。
设置
基于人群的北特伦德拉格健康研究（HUNT2和HUNT3）的数据与挪威医学出生登记处的信息相关联。
参与者
65343名参与者在两项HUNT研究中的任何一项中回答了头痛问题。仅纳入那些在HUNT2或HUNT3中回答了头痛问题且在挪威医学出生登记处（1967年后出生）有分娩方式信息的人。我们的最终样本包括6592名女性和4602名男性，年龄在19 - 41岁之间。
结果
剖宫产情况下偏头痛的比值比。分析在多变量逻辑回归模型中进行。
结果
在调整了性别、年龄和胎儿生长受限因素后，剖宫产与后期偏头痛无关联（比值比0.86，95%置信区间0.64至1.15）。剖宫产与非偏头痛性头痛的比值比降低相关（比值比0.77，95%置信区间0.60至0.99）。
结论
在这项基于人群的登记关联研究中，未发现剖宫产与偏头痛之间存在关联。
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