Chevalier A, Izembart M, Boutteville C, Chopin N, Vallée G
Laboratoire de Biophysique, Centre Hospitalier Universitaire Necker, Paris.
Pathol Biol (Paris). 1987 Nov;35(9):1223-9.
Iodine research holds an increasing place in thyroid pathology, either to cover a radioisotopic investigation with paradoxal results or to find an iatrogenic cause to an unexplained hypo- or hyperthyroidism in new born children as well as in adults. To determine iodine overloads we may need a urinary iodine estimation, in addition to blood iodine determination (quickly eliminated products) or instead of it (difficult blood taking: new born children, etc.). Classically, the 24 hours urinary iodine estimation (total urinary iodine) covers this need but, in practice, as we generally deal with ambulatory patients, the risks linked to the obtention of a perfect 24 hours urine collecting make us abandon it. This article presents an original and simple way of getting round this difficulty: it demonstrates that an excellent iodine overload estimation can be obtained by measuring simultaneously from a simple miction: on one hand iodine concentration, on the other hand the urinary creatinine.
碘研究在甲状腺病理学中所占的地位日益重要，这既体现在涵盖具有矛盾结果的放射性同位素研究方面，也体现在为新生儿及成人不明原因的甲状腺功能减退或亢进寻找医源性病因上。为了确定碘负荷，除了测定血碘（快速消除的产物）之外，我们可能还需要估计尿碘，或者在难以采血的情况下（如新生儿等）仅通过估计尿碘来确定。传统上，24小时尿碘估计（尿碘总量）可满足这一需求，但在实际操作中，由于我们通常面对的是门诊患者，获取完美的24小时尿液收集存在风险，这使得我们放弃了这种方法。本文提出了一种克服这一困难的新颖且简单的方法：它表明通过同时测量单次排尿中的碘浓度和尿肌酐，能够出色地估计碘负荷。
