Kocak Mehmet Nuri, Ates Orhan, Ondas Osman, Kaya Zulkuf
Department of Neurology, Ataturk University School of Medicine, Erzurum, Turkey.
Department of Ophthalmology, Ataturk University School of Medicine, Erzurum, Turkey.
Eurasian J Med. 2020 Oct;52(3):288-291. doi: 10.5152/eurasianjmed.2020.20188.
This study aimed to evaluate the differences in the mean retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) in patients with early stage central vertigo with or without vertebrobasilar stenosis detected by Doppler ultrasound.
A total of 50 patients with ischemic vertigo and 50 healthy individuals were included in the study. The distinction between central and peripheral vertigo was determined by physical and neurological examinations and the Dix-Hallpike maneuver. For all patients, the mean RNFL thickness was determined using OCT performed by 2 independent ophthalmologists.
There were no significant differences between the groups in terms of age and sex distribution (p>0.05). On average, in superior, inferior, and temporal quadrants, there was a statistically significant difference between the control and patient groups (p<0.001).
The retina may be affected in patients with ischemic vertigo because of atherosclerotic ischemic lesions in the carotid and vertebral arteries. Neuroimaging methods and OCT were evaluated together to develop a new diagnostic approach. With OCT, which is a non-invasive method, early and more objective differential diagnosis will be possible.
本研究旨在利用光学相干断层扫描（OCT）评估经多普勒超声检测有或无椎基底动脉狭窄的早期中枢性眩晕患者视网膜神经纤维层（RNFL）平均厚度的差异。
本研究共纳入50例缺血性眩晕患者和50名健康个体。通过体格检查、神经系统检查及 Dix-Hallpike 试验确定中枢性眩晕与周围性眩晕。对所有患者，由2名独立的眼科医生使用OCT测定RNFL平均厚度。
两组在年龄和性别分布方面无显著差异（p>0.05）。平均而言，在上方、下方和颞侧象限，对照组与患者组之间存在统计学显著差异（p<0.001）。
由于颈动脉和椎动脉的动脉粥样硬化性缺血性病变，缺血性眩晕患者的视网膜可能受到影响。联合评估神经影像学方法和OCT以开发新的诊断方法。利用OCT这种非侵入性方法，将有可能进行早期且更客观的鉴别诊断。
