School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Australian e-Health Research Centre, CSIRO, Melbourne, VIC, Australia.
Eur J Neurol. 2021 Apr;28(4):1406-1419. doi: 10.1111/ene.14648. Epub 2020 Dec 6.
Numerous neuroimaging techniques have been used to identify biomarkers of disease progression in Huntington's disease (HD). To date, the earliest and most sensitive of these is caudate volume; however, it is becoming increasingly evident that numerous changes to cortical structures, and their interconnected networks, occur throughout the course of the disease. The mechanisms by which atrophy spreads from the caudate to these cortical regions remains unknown. In this review, the neuroimaging literature specific to T1-weighted and diffusion-weighted magnetic resonance imaging is summarized and new strategies for the investigation of cortical morphometry and the network spread of degeneration in HD are proposed. This new avenue of research may enable further characterization of disease pathology and could add to a suite of biomarker/s of disease progression for patient stratification that will help guide future clinical trials.
已有许多神经影像学技术被用于鉴定亨廷顿病（HD）的疾病进展生物标志物。迄今为止，其中最早和最敏感的标志物是尾状核体积；然而，越来越明显的是，在疾病的整个过程中，皮质结构及其相互连接的网络会发生许多变化。萎缩从尾状核向这些皮质区域扩散的机制尚不清楚。在这篇综述中，总结了 T1 加权和弥散加权磁共振成像的神经影像学文献，并提出了用于研究 HD 中皮质形态计量和变性网络扩散的新策略。这一新的研究途径可以进一步描述疾病的病理学，并可能增加一套用于患者分层的疾病进展生物标志物/，有助于指导未来的临床试验。
