Tan Yi, Wu Hongxiang, Wei Tongyao, Li Xuechen
Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China SAR.
J Am Chem Soc. 2020 Nov 19. doi: 10.1021/jacs.0c09664.
Contemporary chemical protein synthesis has been dramatically advanced over the past few decades, which has enabled chemists to reach the landscape of synthetic biomacromolecules. Chemical synthesis can produce synthetic proteins with precisely controlled structures which are difficult or impossible to obtain via gene expression systems. Herein, we summarize the key enabling ligation technologies, major strategic developments, and some selected representative applications of synthetic proteins and provide an outlook for future development.
在过去几十年中，当代化学蛋白质合成取得了巨大进展，这使化学家能够涉足合成生物大分子领域。化学合成可以产生具有精确可控结构的合成蛋白质，而这些结构通过基因表达系统难以或无法获得。在此，我们总结了合成蛋白质的关键连接技术、主要战略发展以及一些选定的代表性应用，并对未来发展进行了展望。
