Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Biol Macromol. 2021 Jan 15;167:59-65. doi: 10.1016/j.ijbiomac.2020.11.103. Epub 2020 Nov 16.
Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 ± 1.09 mm) and E. coli (11.54± 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application.
最近，具有适当特性的生物相容性可注射水凝胶作为一种理想的伤口敷料，在组织工程领域的应用受到了更多关注。为此，成功开发了负载姜黄素的玉米醇溶蛋白纳米粒子/醛基改性瓜尔胶/丝素（Cur-NPs/OGG/SF）水凝胶网络，以提高姜黄素在伤口处理过程中的生物利用度。对所制备的水凝胶进行了形态学、热稳定性、降解和力学性能评估。通过改变 OGG/SF 的重量比，研究了不含或负载姜黄素的玉米醇溶蛋白纳米粒子的水凝胶的物理化学性能。结果表明，随着 OGG 含量的增加，水凝胶的降解行为得到改善。此外，Cur-NPs/OGG/SF 水凝胶促进了小鼠胚胎成纤维细胞（NIH-3T3）的增殖，对其没有细胞毒性作用。Cur-NPs/OGG/SF 水凝胶对芽孢杆菌（15.26±1.09 mm）和大肠杆菌（11.54±1.36 mm）具有抑制活性。这些结果表明，新型水凝胶可适用于伤口愈合应用。
