Jaenisch R, Soriano P
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.
Symp Fundam Cancer Res. 1986;39:59-65.
Retroviruses have been used as probes for the study of mammalian development. Successful applications of this tool include (1) genetic labeling of cells for lineage studies in preimplantation and postimplantation development, (2) tagging important chromosomal regions of the mouse genome, (3) identifying genes that are expressed during early development, and (4) generating mutant mouse strains by insertional mutations that allow for molecular and functional analyses of developmental genes.
逆转录病毒已被用作研究哺乳动物发育的探针。该工具的成功应用包括：（1）对细胞进行基因标记，用于植入前和植入后发育的谱系研究；（2）标记小鼠基因组的重要染色体区域；（3）鉴定早期发育过程中表达的基因；（4）通过插入突变产生突变小鼠品系，以便对发育基因进行分子和功能分析。
