Department of Radiology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Clin Radiol. 2021 Mar;76(3):238.e9-238.e15. doi: 10.1016/j.crad.2020.10.010. Epub 2020 Nov 16.
To assess the feasibility and preliminary diagnostic performances of relaxation times derived from synthetic magnetic resonance imaging (syMRI) for differentiating nasopharyngeal carcinoma from nasopharyngeal benign lymphoid hyperplasia, and to assess the influence of tissue segmentation method on relaxation estimates.
Fifty participants with nasopharyngeal carcinoma (NPC) and 40 participants with benign hyperplasia (NPH) who underwent syMRI examination were enrolled prospectively. T1, T2, and proton density (PD) values were obtained from four different regions of interest (ROIs), namely, partial-section, single-section, three-sections, and whole-lesion. The metrics between NPC and NPH or among different ROIs were compared using Student's t-test or one-way ANOVA. The area under curve (AUC) was calculated to assess the performance of metrics obtained from different ROIs to differentiate NPC and NPH.
The T1, T2, and PD values for NPH were significantly higher than those for NPC, regardless of the type of ROI used, except for the PD value obtained from the whole-lesion ROI. The T2 values obtained from the single-section ROI showed the highest diagnostic accuracy in distinguishing NPC from NPH, with an AUC of 0.894, sensitivity of 0.900, and specificity of 0.800. Additionally, the T1, T2, and PD values for nasopharyngeal lesions showed no statistical difference among different kinds of ROI, except for the difference in T1 value between partial-section and other methods.
Quantitative analysis of syMRI has the potential to distinguish NPC from NPH. Moreover, different types of ROI showed limited influence on the relaxation time estimation for nasopharyngeal lesions.
评估基于合成磁共振成像（syMRI）的弛豫时间在鉴别鼻咽癌和鼻咽良性淋巴组织增生中的可行性和初步诊断性能，并评估组织分割方法对弛豫估计的影响。
前瞻性纳入 50 例鼻咽癌（NPC）患者和 40 例鼻咽良性淋巴组织增生（NPH）患者，均接受 syMRI 检查。分别从部分截面、单截面、三截面和全病变 4 个感兴趣区（ROI）获得 T1、T2 和质子密度（PD）值。采用Student's t 检验或单因素方差分析比较 NPC 和 NPH 之间或不同 ROI 之间的指标差异。计算曲线下面积（AUC）以评估不同 ROI 获得的指标鉴别 NPC 和 NPH 的性能。
无论使用哪种 ROI 类型，NPH 的 T1、T2 和 PD 值均明显高于 NPC，除了全病变 ROI 获得的 PD 值。单截面 ROI 获得的 T2 值在鉴别 NPC 和 NPH 方面具有最高的诊断准确性，AUC 为 0.894，灵敏度为 0.900，特异度为 0.800。此外，除了部分截面和其他方法之间 T1 值的差异外，不同类型 ROI 之间的鼻咽病变 T1、T2 和 PD 值均无统计学差异。
syMRI 的定量分析有可能区分 NPC 和 NPH。此外，不同类型的 ROI 对鼻咽病变弛豫时间的估计影响有限。
