Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241000, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241000, China.
Sci Rep. 2023 Apr 28;13(1):6964. doi: 10.1038/s41598-023-33955-w.
Gastric cancer (GC) is the most common gastrointestinal cancer and the leading cause of worldwide cancer-associated mortality. Several GC patients are diagnosed at the advanced stage with an unsatisfactory 5-year survival rate. Rab1A was significantly associated with IL4Rα expression in non-small cell lung cancer. However, their potential correlation in expression and prognosis remains largely unknown in GC. In this study, Rab1A/IL-4Rα was significantly increased in GC than in para-cancerous tissues, and Rab1A/IL-4Rα overexpression caused poor prognosis among GC patients. Rab1A expression was significantly correlated with IL-4Rα expression in GC tissues, as determined by IHC analysis. In addition, the mRNA expression of Rab1A was closely linked with the IL-4Rα mRNA expression in GC tissue expressed by qPCR. Furthermore, the Kaplan-Meier analysis demonstrated that the group with negative Rab1A and IL-4Rα expression had longer 5-year survival rates than the other group. Besides, the group with positive Rab1A and IL-4Rα expression had a worse prognosis than the other group. Finally, nomograms revealed the overall 3 and 5-year survival determined crucial roles of Rab1A/IL-4Rα expression in predicting the prognosis of GC patients. Therefore, Rab1A/IL-4Rα is vital in GC, providing a novel perspective on targeted GC therapy.
胃癌（GC）是最常见的胃肠道癌症，也是全球癌症相关死亡率的主要原因。许多 GC 患者被诊断为晚期，5 年生存率不理想。Rab1A 与非小细胞肺癌中的 IL4Rα 表达显著相关。然而，它们在 GC 中的表达和预后的潜在相关性在很大程度上仍然未知。在这项研究中，Rab1A/IL-4Rα 在 GC 组织中明显高于癌旁组织，Rab1A/IL-4Rα 过表达导致 GC 患者预后不良。通过免疫组化分析，确定 Rab1A 在 GC 组织中与 IL-4Rα 的表达呈显著相关。此外，qPCR 检测到 GC 组织中 Rab1A 的 mRNA 表达与 IL-4Rα mRNA 表达密切相关。此外，Kaplan-Meier 分析表明，Rab1A 和 IL-4Rα 表达均为阴性的组 5 年生存率高于其他组。此外，Rab1A 和 IL-4Rα 表达均为阳性的组预后比其他组差。最后，列线图显示，Rab1A/IL-4Rα 表达对预测 GC 患者预后的总 3 年和 5 年生存率起着至关重要的作用。因此，Rab1A/IL-4Rα 在 GC 中很重要，为 GC 的靶向治疗提供了新的视角。
