ANSH: Multimodal Neuroimaging Database Including MR Spectroscopic Data From Each Continent to Advance Alzheimer's Disease Research.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people worldwide. The etiology of AD is not known, and intense research involving multimodal neuroimaging data (e.g., MRI, functional MRI, PET etc.) is extensively used to identify the causal molecular process for AD. In this context, various imaging-based databases accessible to researchers globally, are useful for an independent analysis. Apart from MRI-based brain imaging data, the neurochemical data using magnetic resonance spectroscopy (MRS) provide early molecular processes before the structural or functional changes are manifested. The existing imaging-based databases in AD lack the integration of MRS modality and, thus, limits the availability of neurochemical information to the AD research community. This perspective is an initiative to bring attention to the development of the neuroimaging database, "ANSH," that includes brain glutathione (GSH), gamma aminobutyric acid (GABA) levels, and other neurochemicals along with MRI-based information for AD, mild cognitive impairment (MCI), and healthy subjects. ANSH is supported by a JAVA-based workflow environment and python providing a simple, dynamic, and distributed platform with data security. The platform consists of two-tiered architecture for data collection and management further supporting quality control, report generation for analyzed data, and data backup with a dedicated storage system. The ANSH database aims to present a single neuroimaging data platform incorporating diverse data types from healthy control and patient groups to provide better insights pertaining to disease progression. This data management platform provides flexible data sharing across users with continuous project monitoring. The development of ANSH platform will facilitate collaborative research and multi-site data sharing across the globe.