Department of Pharmacokinetics/Pharmacodynamics, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, USA.
Department of Pharmacy, Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University, Box 580, SE-751 23, Uppsala, Sweden.
Pharm Res. 2020 Nov 19;37(12):244. doi: 10.1007/s11095-020-02968-9.
This study assessed the perception of sweetness, creaminess, and pleasantness from a sweet/fat preference test in subjects who are lean (BMI: 19-25), obese (BMI: 30-33) or very obese (BMI: 34-40) using categorical modeling.
Subjects tasted 16 dairy solutions consisting of 0%, 3.5%, 11.3% and 37.5% fat and each containing 0%, 5%, 10%, or 20% sugar and rated them for sweetness, creaminess and pleasantness.
A proportional odds model described the perception of sweetness using an Emax for the effect of sugar and a linear effect for fat. Perception of creaminess was dependent on the fat and sugar content and was described with proportional odds model with linear effects of sugar and fat. Perception of pleasantness increased with sugar and fat but decreased in solutions containing 37.5% fat. A differential odds model using an Emax model for fat and sugar with a negative interaction between them allowed the sugar content to be less than proportional and the fat content to be greater than proportional for pleasantness.
Application of modeling provided understanding of these complex interactions of sugar and fat on the perception of sweetness, creaminess, and pleasantness and provides a tool to investigate obesity and pharmacological intervention.
本研究使用分类模型评估了瘦(BMI:19-25)、肥胖(BMI:30-33)和非常肥胖(BMI:34-40)受试者在甜味/脂肪偏好测试中对甜度、奶油感和愉悦感的感知。
受试者品尝了 16 种乳制品溶液,包含 0%、3.5%、11.3%和 37.5%的脂肪,每种溶液含有 0%、5%、10%或 20%的糖,并对它们的甜度、奶油感和愉悦感进行了评分。
比例优势模型使用糖的 Emax 和脂肪的线性效应描述了对甜度的感知。奶油感取决于脂肪和糖的含量,并用具有糖和脂肪线性效应的比例优势模型来描述。愉悦感随着糖和脂肪的增加而增加,但在含有 37.5%脂肪的溶液中减少。使用 Emax 模型的差异优势模型对脂肪和糖进行建模,并对它们之间的负相互作用进行建模,使得糖的含量不成比例地减少,而脂肪的含量不成比例地增加,从而对愉悦感产生影响。
模型应用提供了对糖和脂肪对甜度、奶油感和愉悦感感知的这些复杂相互作用的理解,并提供了一种工具来研究肥胖和药物干预。