Barnes D J, Naraqi S, Igo J D
Division of Medicine, Medical Faculty, University of Papua New Guinea.
Thorax. 1987 Nov;42(11):889-91. doi: 10.1136/thx.42.11.889.
In a prospective study of 170 adult patients with acute pneumonia, Haemophilus influenzae was found to be the aetiological agent in 15 cases (8.8%). The diagnosis in all cases was based on positive cultures of blood or percutaneous lung aspirate, or both. Chronic lung disease was significantly more common in patients with H influenzae pneumonia than in patients with pneumonia due to other organisms but age, sex, and smoking history did not differ significantly. Lobar consolidation was the most common radiological pattern, being present in 10 of the 15 cases. Type b was the commonest serotype isolated, but three cases were due to non-typable (non-capsulate) strains. All patients survived, responding well to treatment with penicillin, ampicillin, or chloramphenicol. Haemophilus influenzae should be considered as a possible cause of pneumonia in adults, particularly those with underlying chronic lung disease.
在一项针对170例成年急性肺炎患者的前瞻性研究中，发现15例（8.8%）的病因是流感嗜血杆菌。所有病例的诊断均基于血液或经皮肺穿刺抽吸物培养阳性，或两者均为阳性。流感嗜血杆菌肺炎患者的慢性肺病明显比其他病原体所致肺炎患者更为常见，但年龄、性别和吸烟史无显著差异。大叶实变是最常见的影像学表现，15例中有10例出现。分离出的最常见血清型为b型，但有3例是由不可分型（无荚膜）菌株引起的。所有患者均存活，对青霉素、氨苄西林或氯霉素治疗反应良好。流感嗜血杆菌应被视为成人肺炎的可能病因，尤其是那些患有潜在慢性肺病的患者。
