Department of Clinical Laboratory, The First Hospital of Changsha City, Hunan, People's Republic of China, Hunan, China.
Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11386-11394. doi: 10.26355/eurrev_202011_23631.
To explore the expression and significance of SAA, CRP and FERR in patients diagnosed with COVID-19.
A total of 225 patients diagnosed with COVID-19 who were admitted to the North Hospital of First Hospital in Changsha, China, from 9th February 2020 to 7th March 2020 were enrolled. Their general data, laboratory test results and levels of SAA, CRP and FERR were extracted from electronic medical records.
Age was an important risk factor for the severity of COVID-19 in the patients. Compared with the non-severe group, the severe group showed statistical significance in the levels of total protein, albumin, ALT and AST in liver function, UA in renal function, myocardial enzyme CK-MB and LDH, and immunoglobulin IgG and IgM. The levels of SAA, CRP, and FERR were significantly increased in patients with severe COVID-19. ROC curve analysis results showed that the AUC, from small to large, was as follows: SAA+CRP+FERR, CRP + FERR, SAA + CRP, SAA + FERR, SAA, FERR, and CRP, which indicated the benefit of the combination of the three indicators. The sensitivity and specificity of the combined detection of the three indicators were higher than those of the detection of any single indicator or two combined indicators. A Spearman correlation analysis of the data showed that the initial CRP/SAA, SAA/FERR, and CRP/FERR were positively correlated. The continuous results of SAA, CRP and FERR throughout the study period showed that the values of the severe group on a given day were higher than those of the non-severe group; the values of the two groups peaked on the 5th or 7th day and then decreased, and the decreasing trend of the severe group was more evident.
SAA, CRP and FERR are sensitive serological indicators used to evaluate the severity of COVID-19. The combined detection of serum SAA, FERR, and CRP, which are positively related to COVID-19 infection, offers guiding significance for the occurrence of COVID-19 infection and the severity of the disease. Such detection provides effective detection indicators for the progress and prognosis of COVID-19; these indicators will enable effective intervention measures to be implemented in time and the rates of severe illness and mortality to be reduced.
探讨血清淀粉样蛋白 A（SAA）、C 反应蛋白（CRP）和铁蛋白（FERR）在新型冠状病毒肺炎（COVID-19）患者中的表达及意义。
选取 2020 年 2 月 9 日至 3 月 7 日期间于长沙市第一医院北院收治的 225 例 COVID-19 患者，提取其一般资料、实验室检查结果及 SAA、CRP 和 FERR 水平。
年龄是 COVID-19 患者病情严重程度的重要危险因素。与非重症组比较，重症组患者总蛋白、白蛋白、肝功能 ALT 和 AST、肾功能 UA、心肌酶 CK-MB 和 LDH 及免疫球蛋白 IgG 和 IgM 水平差异有统计学意义；重症组 SAA、CRP 和 FERR 水平显著升高。ROC 曲线分析结果显示，AUC 由小到大依次为：SAA+CRP+FERR、CRP+FERR、SAA+CRP、SAA+FERR、SAA、FERR 和 CRP，提示联合检测 3 项指标更具优势。3 项指标联合检测的敏感度和特异度均高于单项或两项联合检测。Spearman 相关性分析结果显示，初始 CRP/SAA、SAA/FERR、CRP/FERR 呈正相关。整个研究期间 SAA、CRP 和 FERR 的连续结果显示，重症组在某一天的数值高于非重症组；两组均在第 5 天或第 7 天达到峰值，然后下降，重症组下降趋势更为明显。
SAA、CRP 和 FERR 是评估 COVID-19 严重程度的敏感血清学指标。联合检测与 COVID-19 感染呈正相关的血清 SAA、FERR 和 CRP，对 COVID-19 感染的发生及疾病严重程度具有指导意义，为 COVID-19 的病情进展及预后提供了有效的检测指标，以便及时采取有效的干预措施，降低重症率和病死率。
