Butler Rickeem, Bradford David, Rodgers Kathleen E
Department of Medical Pharmacology, Center for Innovation in Brain Science, University of Arizona College of Medicine, Tucson, AZ, United States.
Front Aging Neurosci. 2022 Nov 29;14:1006089. doi: 10.3389/fnagi.2022.1006089. eCollection 2022.
In this review, the relationship between bioenergetics, mitochondrial dysfunction, and inflammation will be and how they contribute to neurodegeneration, specifically in Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) will be reviewed. Long-term changes in mitochondrial function, autophagy dysfunction, and immune activation are commonalities shared across these age-related disorders. Genetic risk factors for these diseases support an autophagy-immune connection in the underlying pathophysiology. Critical areas of deeper evaluation in these bioenergetic processes may lead to potential therapeutics with efficacy across multiple neurodegenerative diseases.
在本综述中，将探讨生物能量学、线粒体功能障碍与炎症之间的关系，以及它们如何导致神经退行性变，特别是在阿尔茨海默病（AD）、肌萎缩侧索硬化症（ALS）和多发性硬化症（MS）中的作用机制。线粒体功能的长期变化、自噬功能障碍和免疫激活是这些与年龄相关疾病的共同特征。这些疾病的遗传风险因素支持了潜在病理生理学中自噬与免疫的联系。对这些生物能量学过程进行更深入评估的关键领域可能会带来对多种神经退行性疾病有效的潜在治疗方法。
