Neurosurgery Department, Gui de Chauliac Hospital, Montpellier University Medical Center, 91 avenue Augustin Fliche, 34090, Montpellier, France.
APHP, Groupe Hospitalo-Universitaire Pitié-Salpétrière, Neurosurgery Department, Sorbonne Université, Paris, France.
Acta Neurochir (Wien). 2021 Jan;163(1):57-66. doi: 10.1007/s00701-020-04650-w. Epub 2020 Nov 20.
Meningiomas are tumors arising from the meninges and represent the most frequent central nervous system tumors in adults. Recent large-scale genetic studies and preclinical meningioma mouse modelling led to a better comprehension of meningioma development and suggested evidences of close relationships between meningeal embryology and tumorigenesis. In this non-systematic review, we summarize the current knowledge on meningeal embryology and developmental biology, and illustrate how meningioma tumorigenesis is deeply related to meningeal embryology, concerning the potential cell of origin, the role of reactivation of embryonic stem cells, the influence of the embryonic tissue of origin, and the parallelism between topography-dependant molecular pathways involved in normal meninges and in meningioma development. Our study emphasizes why future studies on meningeal embryology are mandatory to affine our comprehension of mechanisms underlying meningioma initiation and development.
脑膜瘤起源于脑膜，是成人中枢神经系统最常见的肿瘤。最近的大规模遗传研究和脑膜瘤小鼠模型研究使人们对脑膜瘤的发生有了更好的理解，并提示脑膜胚胎学与肿瘤发生之间存在密切关系。在本次非系统性综述中，我们总结了脑膜胚胎学和发育生物学的现有知识，并说明了脑膜瘤的发生与脑膜胚胎学密切相关，包括潜在的起源细胞、胚胎干细胞激活的作用、起源组织的影响，以及正常脑膜和脑膜瘤发展过程中涉及的拓扑相关分子途径之间的平行关系。我们的研究强调了为什么未来对脑膜胚胎学的研究对于加深我们对脑膜瘤发生和发展机制的理解是必要的。
