Department of Psychiatry, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Department of Psychiatry, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
AIDS Behav. 2021 Jun;25(6):1711-1728. doi: 10.1007/s10461-020-03100-z. Epub 2020 Nov 20.
In sub-Saharan Africa (SSA), a systematic approach to exploring the prevalence of psychiatric disorders (PDs) and adherence to antiretroviral treatment (ART) in adolescents living with HIV (ALWHIV) is lacking. This study aimed to systematically review the studies conducted in SSA on the prevalence of PDs among ALWHIV and their association with ART adherence. A systematic search of all English studies assessing PDs among ALWHIV using the Web of Science, PubMed, and EBSCO databases was conducted between March 1 and September 30, 2019. Forty-two studies published between 2009 to 2019 met the inclusion criteria, of which 15 were included in the meta-analysis. The most common PDs were depression (0.24, 95% CI 0.14-0.36) and anxiety disorder (0.26, 95% CI 2-0.44). The available evidence could not conclude on the definitive association between PDs and ART adherence; therefore, further research is required. However, the need for mental health integration in the care for ALWHIV is evident.
在撒哈拉以南非洲（SSA），缺乏一种系统的方法来探索艾滋病毒青少年感染者（ALWHIV）中精神障碍（PDs）的流行情况和抗逆转录病毒治疗（ART）的依从性。本研究旨在系统地回顾在 SSA 进行的评估 ALWHIV 中 PDs 患病率及其与 ART 依从性之间关系的研究。在 2019 年 3 月 1 日至 9 月 30 日期间，使用 Web of Science、PubMed 和 EBSCO 数据库对评估 ALWHIV 中 PDs 的所有英文研究进行了系统搜索。符合纳入标准的 42 项研究发表于 2009 年至 2019 年之间，其中 15 项纳入荟萃分析。最常见的 PDs 是抑郁症（0.24，95%CI 0.14-0.36）和焦虑症（0.26，95%CI 0.20-0.44）。现有证据无法确定 PDs 与 ART 依从性之间的明确关联；因此，需要进一步研究。然而，显然需要将心理健康纳入 ALWHIV 的护理中。
