CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Galway, H91W2TY, Ireland.
School of Chemistry, Ryan Institute, National University of Ireland Galway, Galway, H91CF50, Ireland.
Adv Mater. 2021 Jan;33(2):e2003883. doi: 10.1002/adma.202003883. Epub 2020 Nov 20.
The fabrication of biomimetic catalysts as substituents for enzymes is of critical interest in the field due to the problems associated with the extraction, purification, and storage of enzymes in sensing applications. Of these mimetics, hemin/coordination polymer-based nanocomposites, mainly hemin/metal-organic frameworks (MOF), have been developed for various biosensing applications because of the unique properties of each component, while trying to mimic the normal biological functions of heme within the protein milieu of enzymes. This critical review first discusses the different catalytic functions of heme in the body in the form of enzyme/protein structures. The properties of hemin dimerization are then elucidated with the supposed models of hemin oxidation. After that, the progress in the fabrication of hemin/MOF nanocomposites for the sensing of diverse biological molecules is discussed. Finally, the challenges in developing this type of composites are examined as well as possible proposals for future directions to enhance the sensing performance in this field further.
仿生催化剂的制备作为酶的替代品在该领域具有重要意义，因为在传感应用中，酶的提取、纯化和储存存在问题。在这些模拟物中，基于血红素/配位聚合物的纳米复合材料，主要是血红素/金属有机骨架（MOF），已经被开发用于各种生物传感应用，因为每个组件都具有独特的性质，同时试图模拟酶的蛋白质环境中血红素的正常生物学功能。这篇重要的综述首先讨论了血红素在体内以酶/蛋白质结构的不同催化功能。然后阐明了血红素二聚化的性质，并提出了血红素氧化的假设模型。之后，讨论了用于检测各种生物分子的血红素/MOF 纳米复合材料的制备进展。最后，还检查了开发这种类型复合材料的挑战以及可能的建议，以进一步提高该领域的传感性能。
