Carpenter Janet S, Tisdale James E, Chen Chen X, Kovacs Richard, Larson Joseph C, Guthrie Katherine A, Ensrud Kristine E, Newton Katherine M, LaCroix Andrea Z
School of Nursing, Indiana University, Indianapolis, Indiana, USA.
College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.
J Womens Health (Larchmt). 2021 Apr;30(4):533-538. doi: 10.1089/jwh.2020.8586. Epub 2020 Nov 20.
Study to describe the degree of menopausal palpitation distress and its demographic, clinical, symptom, and quality-of-life (QOL) correlates. Analysis of existing, baseline, data from peri- and postmenopausal women, 42 to 62 years of age, who participated in the Menopause Strategies-Finding Lasting Answers for Symptoms and Health (MsFLASH) clinical trials testing interventions for vasomotor symptoms ( = 759). Up to 46.8% of menopausal women report having palpitations, yet the symptom is relatively understudied. Little is known about palpitation distress or its correlates. Degree of distress from "heart racing or pounding" was self-reported over the past two weeks as "not at all," "a little bit," "moderately," "quite a bit," or "extremely." Other measures included self-report forms, clinic-verified body mass index (BMI), vasomotor symptom diaries, and validated symptom and QOL tools. The percentage who reported palpitation distress was 19.6%, 25.2%, and 33.5% in the three trials or 25.0% overall. In multivariate analysis, the odds of reporting palpitation distress was lower in past smokers (odds ratio [OR] = 0.59 [95% confidence interval (CI) 0.38-0.90]) and current smokers (OR = 0.48 [0.27-0.87]) relative to never-smokers and lower with every 5 kg/m higher BMI (OR = 0.82 [0.69-0.98]).The odds of reporting palpitation distress was higher with every five point more severe insomnia (OR = 1.28 [1.05-1.54]), five point worse depressive symptoms (OR = 1.47 [1.11-1.95]), five point worse perceived stress (OR = 1.19 [1.01-1.39]), and one point worse menopausal QOL (OR = 1.29 [1.06-1.57]). Menopausal palpitation distress is common and associated with demographic, clinical, symptom, and QOL factors. Findings can be used for screening in clinical practice and to justify additional research on this understudied symptom.
本研究旨在描述绝经后心悸困扰的程度及其与人口统计学、临床、症状和生活质量（QOL）的相关性。对年龄在42至62岁之间、参与绝经策略——寻找症状与健康的持久答案（MsFLASH）临床试验（该试验测试血管舒缩症状的干预措施，n = 759）的围绝经期和绝经后女性的现有基线数据进行分析。高达46.8%的绝经后女性报告有心悸症状，但对该症状的研究相对较少。关于心悸困扰及其相关性知之甚少。过去两周内，“心跳加速或怦怦跳”的困扰程度通过自我报告分为“完全没有”“有一点”“中等程度”“相当严重”或“极其严重”。其他测量指标包括自我报告表、经诊所核实的体重指数（BMI）、血管舒缩症状日记以及经过验证的症状和生活质量工具。在三项试验中，报告有心悸困扰的百分比分别为19.6%、25.2%和33.5%，总体为25.0%。在多变量分析中，与从不吸烟者相比，既往吸烟者（优势比[OR]=0.59[95%置信区间（CI）0.38 - 0.90]）和当前吸烟者（OR = 0.48[0.27 - 0.87]）报告心悸困扰的几率较低，且BMI每升高5kg/m²，几率也较低（OR = 0.82[0.69 - 0.98]）。失眠每加重5分（OR = 1.28[1.05 - 1.54]）、抑郁症状每加重5分（OR = 1.47[1.11 - 1.95]）、感知压力每加重5分（OR = 1.19[1.01 - 1.39]）以及绝经后生活质量每降低1分（OR = 1.29[1.06 - 1.57]），报告心悸困扰的几率就会更高。绝经后心悸困扰很常见，且与人口统计学、临床、症状和生活质量因素相关。研究结果可用于临床实践中的筛查，并为对这一研究较少的症状进行更多研究提供依据。
