瑜伽对血管舒缩症状的疗效：一项随机对照试验。
Efficacy of yoga for vasomotor symptoms: a randomized controlled trial.
作者信息
Newton Katherine M, Reed Susan D, Guthrie Katherine A, Sherman Karen J, Booth-LaForce Cathryn, Caan Bette, Sternfeld Barbara, Carpenter Janet S, Learman Lee A, Freeman Ellen W, Cohen Lee S, Joffe Hadine, Anderson Garnet L, Larson Joseph C, Hunt Julie R, Ensrud Kristine E, LaCroix Andrea Z
机构信息
From the 1Group Health Research Institute, Seattle, WA; 2Departments of Obstetrics/Gynecology and Epidemiology, University of Washington School of Medicine, Seattle, WA; 3Data Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA; 4School of Nursing, University of Washington, Seattle, WA; 5Division of Research, Kaiser Permanente Medical Program of Northern California, Oakland, CA; 6School of Nursing, Indiana University, Indianapolis, IN; 7Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN; 8Department of Obstetrics/Gynecology, University of Pennsylvania, Philadelphia, PA; 9Massachusetts General Hospital, Boston, MA; 10Department of Medicine, VA Medical Center, Minneapolis, MN; and 11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
出版信息
Menopause. 2014 Apr;21(4):339-46. doi: 10.1097/GME.0b013e31829e4baa.
OBJECTIVE
This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother.
METHODS
This study was a three-by-two factorial, randomized controlled trial. Eligible women were randomized to yoga (n = 107), exercise (n = 106), or usual activity (n = 142), and were simultaneously randomized to a double-blind comparison of ω-3 fatty acid (n = 177) or placebo (n = 178) capsules. Yoga intervention consisted of 12 weekly 90-minute yoga classes with daily home practice. Primary outcomes were VMS frequency and bother assessed by daily diaries at baseline, 6 weeks, and 12 weeks. Secondary outcomes included insomnia symptoms (Insomnia Severity Index) at baseline and 12 weeks.
RESULTS
Among 249 randomized women, 237 (95%) completed 12-week assessments. The mean baseline VMS frequency was 7.4 per day (95% CI, 6.6 to 8.1) in the yoga group and 8.0 per day (95% CI, 7.3 to 8.7) in the usual activity group. Intent-to-treat analyses included all participants with response data (n = 237). There was no difference between intervention groups in the change in VMS frequency from baseline to 6 and 12 weeks (mean difference [yoga--usual activity] from baseline at 6 wk, -0.3 [95% CI, -1.1 to 0.5]; mean difference [yoga--usual activity] from baseline at 12 wk, -0.3 [95% CI, -1.2 to 0.6]; P = 0.119 across both time points). Results were similar for VMS bother. At week 12, yoga was associated with an improvement in insomnia symptoms (mean difference [yoga - usual activity] in the change in Insomnia Severity Index, 1.3 [95% CI, -2.5 to -0.1]; P = 0.007).
CONCLUSIONS
Among healthy women, 12 weeks of yoga class plus home practice, compared with usual activity, do not improve VMS frequency or bother but reduce insomnia symptoms.
目的
本研究旨在确定瑜伽在减轻血管舒缩症状（VMS）的频率及困扰方面的疗效。
方法
本研究为三因素二水平析因随机对照试验。符合条件的女性被随机分为瑜伽组（n = 107）、运动组（n = 106）或日常活动组（n = 142），同时被随机分为ω-3脂肪酸胶囊双盲比较组（n = 177）或安慰剂组（n = 178）。瑜伽干预包括每周12次、每次90分钟的瑜伽课程，并辅以每日在家练习。主要结局指标为通过基线、6周和12周的每日日记评估的VMS频率及困扰。次要结局指标包括基线和12周时的失眠症状（失眠严重程度指数）。
结果
在249名随机分组的女性中，237名（95%）完成了12周的评估。瑜伽组的平均基线VMS频率为每天7.4次（95%CI，6.6至8.1），日常活动组为每天8.0次（95%CI，7.3至8.7）。意向性分析纳入了所有有反应数据的参与者（n = 237）。干预组从基线到6周和12周的VMS频率变化无差异（6周时瑜伽组与日常活动组相比，与基线的平均差值为-0.3[95%CI，-1.1至0.5]；12周时瑜伽组与日常活动组相比，与基线的平均差值为-0.3[95%CI，-1.2至0.6]；两个时间点的P值均为0.119）。VMS困扰的结果相似。在第12周时，瑜伽与失眠症状的改善相关（失眠严重程度指数变化的瑜伽组与日常活动组的平均差值为1.3[95%CI，-2.5至-0.1]；P = 0.007）。
结论
在健康女性中，与日常活动相比，12周的瑜伽课程加在家练习并不能改善VMS频率或困扰，但能减轻失眠症状。
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