甘草泻心汤联合美沙拉嗪治疗溃疡性结肠炎：一项系统评价与Meta分析方案
Gancao Xiexin decoction combined with mesalazine in the treatment of ulcerative colitis: A protocol for a systematic review and meta-analysis.
作者信息
Zhong Chun, Cheng Xiaoming, Jia Bo, Xiong PeiYu, Lu Jinhua, Zhang Peixu, Liu Xinglong, Chen Yunhui
机构信息
School of Basic Medical Science, Chengdu University of Traditional Chinese Medicine, Chengdu.
XiangYang Hospital of Traditional Chinese Medicine, Xiangyang, China.
出版信息
Medicine (Baltimore). 2020 Nov 20;99(47):e23038. doi: 10.1097/MD.0000000000023038.
BACKGROUD
Ulcerative colitis (UC) is a chronic inflammatory disease that involves the rectum, colon and ileum. Gancao Xiexin decoction (GCXXD) is a classic herbal formula in Shanghanlun. More and more research evidence shows that GCXXD has a certain therapeutic effect on UC. Therefore, we designed this study protocol aim to evaluate the efficacy and safety of GCXXD combine with mesalazine for UC.
METHODS
We will systematically search 6 databases, including PubMed, the Cochrane Library, EMBASE, CNKI, VIP, Wang-fang database up to July 2020 to obtain eligible studies. The primary outcomes will focus on the clinical effectiveness. Review Manager 5.3 software will be used for data analysis.
RESULTS
This study will provide the systematic evidence of UC treated with GCXXD combine with mesalazine.
CONCLUSION
The findings of this meta-analysis will provide evidence to judge whether GCXXD combine with mesalazine is a more effective intervention compare to mesalazine only for patient of UC.
INPLASY REGISTRATION NUMBER
INPLASY202080008.
背景
溃疡性结肠炎（UC）是一种累及直肠、结肠和回肠的慢性炎症性疾病。甘草泻心汤（GCXXD）是《伤寒论》中的经典中药方剂。越来越多的研究证据表明，GCXXD对UC有一定的治疗作用。因此，我们设计了本研究方案，旨在评估GCXXD联合美沙拉嗪治疗UC的疗效和安全性。
方法
我们将系统检索6个数据库，包括截至2020年7月的PubMed、Cochrane图书馆、EMBASE、中国知网（CNKI）、维普资讯（VIP）、万方数据库，以获取符合条件的研究。主要结局将聚焦于临床疗效。将使用Review Manager 5.3软件进行数据分析。
结果
本研究将提供GCXXD联合美沙拉嗪治疗UC的系统证据。
结论
本荟萃分析的结果将为判断GCXXD联合美沙拉嗪相对于仅使用美沙拉嗪治疗UC患者是否为更有效的干预措施提供证据。
国际系统评价计划书注册号
INPLASY202080008。
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