Chen Yan-Lei, Shi Hai-Yun, Ma Ting-Ting, Wang Xue-Yan
Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Medicine (Baltimore). 2020 Nov 20;99(47):e23301. doi: 10.1097/MD.0000000000023301.
The clinical epidemiological characteristics of chronic urticaria (CU) in different populations were not completely consistent, and the epidemiological characteristics of CU were very complex. At present, there were some patient-based studies on CU, but few natural population-based studied in the world.This study aimed to analysis the prevalence of self-reported CU among adults in grasslands of northern China and its closely related factors.A multistage and proportionately stratified random sampling with a field interviewer-administered survey study was performed together with skin prick tests (SPT) and measurements of the daily pollen count.A total of 3406 subjects completed the study. The prevalence of self-reported CU was 5.61% (n = 191), which was higher in women than that of men (6.91% vs 4.08%, X = 12.785, P < .001). Seasonal or seasonal aggravation CU accounted for 110 (57.59%) patients. Pollen dispersal season was basically consistent with the peak season of CU, but there was no significant difference in the positive rate of pollen SPT between CU with seasonal or seasonal aggravation symptom and CU with free of symptom (X = 0.425, P = .51), as well as between CU with seasonal or seasonal aggravation symptom and perennial CU (X = 0.439, P = .51). Eczema (odds ratio [OR] = 2.807, P < .001), chronic diarrhea (OR = 2.486, P < .01), food allergy history (OR = 1.890, P < .01), history of family allergy (OR = 1.800, P < .001), and conjunctivitis (OR = 1.749, P < .01) were closely related to CU.This investigation provided the factors closely related to CU, and provided certain ideas for further research on the etiology and prevention of CU.
不同人群慢性荨麻疹（CU）的临床流行病学特征并不完全一致，且CU的流行病学特征非常复杂。目前，有一些基于患者的CU研究，但全球范围内基于自然人群的研究较少。本研究旨在分析中国北方草原地区成年人中自我报告的CU患病率及其密切相关因素。采用多阶段按比例分层随机抽样，由现场访员进行问卷调查，并同时进行皮肤点刺试验（SPT）和每日花粉计数测量。共有3406名受试者完成了研究。自我报告的CU患病率为5.61%（n = 191），女性患病率高于男性（6.91%对4.08%，X = 12.785，P <.001）。季节性或季节性加重的CU患者有110例（57.59%）。花粉传播季节与CU的高发季节基本一致，但季节性或季节性加重症状的CU与无症状CU之间花粉SPT阳性率无显著差异（X = 0.425，P = 0.51），季节性或季节性加重症状的CU与常年性CU之间也无显著差异（X = 0.439，P = 0.51）。湿疹（优势比[OR] = 2.807，P <.001）、慢性腹泻（OR = 2.486，P <.01）、食物过敏史（OR = 1.890，P <.01）、家族过敏史（OR = 1.800，P <.001）和结膜炎（OR = 1.749，P <.01）与CU密切相关。本调查提供了与CU密切相关的因素，为进一步研究CU的病因及预防提供了一定思路。
