Duncan M W, Person D A, Rich R R, Sharp J T
Arthritis Rheum. 1977 Jul-Aug;20(6):1174-8. doi: 10.1002/art.1780200603.
The effects of aspirin on delayed hypersensitivity were assessed in 40 healthy subjects who were randomly assigned to two equal groups. In a double-blind format, the individuals in one group were placed on 4 gm aspirin daily for 5 days, and individuals in the other group were given placebo. Lymphocyte proliferation was measured before and 72 hours after the initiation of drug, by using three mitogens and four antigens. The percentages of T and B lymphocytes were likewise measured before and during therapy. The subjects were skin tested with the same four antigens 72 hours after the initiation of drug, and the skin tests were read 48 hours later. No significant differences between the two groups were detected when skin tests, lymphocyte proliferation, and percentage of T lymphocytes were compared.
在40名健康受试者中评估了阿司匹林对迟发型超敏反应的影响，这些受试者被随机分为两个相等的组。采用双盲方式，一组受试者每天服用4克阿司匹林，持续5天，另一组受试者服用安慰剂。在开始用药前和用药72小时后，使用三种促细胞分裂剂和四种抗原测量淋巴细胞增殖。同样在治疗前和治疗期间测量T淋巴细胞和B淋巴细胞的百分比。在开始用药72小时后，用相同的四种抗原对受试者进行皮肤试验，并在48小时后读取皮肤试验结果。比较皮肤试验、淋巴细胞增殖和T淋巴细胞百分比时，未发现两组之间有显著差异。
