Elliott S T, Hanifin J M
Arch Dermatol. 1979 Jan;115(1):36-9.
Studies of cell mediated immunity (CMI) in atopic dermatitis have demonstrated various defects and frequently contradictory results. The true nature of immune dysfunction remains uncertain. We approached this question by concurrently examining two aspects of CMI: delayed cutaneous hypersensitivity and in vitro lymphocyte transformation. Responses were tested using the antigens Candida albicans and streptokinase-streptodornase (SKSD). Mean lymphocyte transformation was equal in atopic patients and controls, although a subgroup of severely dermatitic patients showed depressed responses. Cutaneous anergy was the rule in atopic patients (96% to candidin and 84% to SKSD). Although normal subjects showed good correlation between in vitro and cutaneous responses, atopic patients showed a significant lack of correlation. Many patients manifested cutaneous anergy in the face of normal lymphocyte transformation re sponses.
对特应性皮炎患者细胞介导免疫（CMI）的研究显示出各种缺陷，且结果常常相互矛盾。免疫功能障碍的真正本质仍不确定。我们通过同时检测CMI的两个方面来探讨这个问题：迟发性皮肤超敏反应和体外淋巴细胞转化。使用白色念珠菌和链激酶-链道酶（SKSD）抗原检测反应。特应性患者和对照组的平均淋巴细胞转化率相同，尽管一部分严重皮炎患者的反应较低。特应性患者中皮肤无反应是常见现象（对念珠菌素无反应的占96%，对SKSD无反应的占84%）。虽然正常受试者的体外反应和皮肤反应之间有良好的相关性，但特应性患者的相关性明显缺乏。许多患者在淋巴细胞转化反应正常的情况下表现出皮肤无反应。
