Emerg Infect Dis. 2020 Dec;26(12):2881-2886. doi: 10.3201/eid2612.191482.
Hepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent-treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent-treated plasma. HEV RNA viral loads were 433 IU in lot A and 55 IU in lot B. Retrospective studies found that 100% (13/13) of evaluable lot A recipients versus 18% (3/17) of evaluable lot B recipients had been infected by HEV (p<0.001), albeit not necessarily at time of transfusion. Among evaluable recipients, 86% with a transfused HEV RNA load >50,000 IU were infected, most likely by the HEV-containing solvent/detergent-treated plasma, versus only 7% with a transfused HEV RNA load <50,000 IU (p<0.001). Overall, solvent/detergent-treated plasma might harbor HEV. Such an occurrence might result in a dose-dependent risk for transfusion-transmitted hepatitis E.
戊型肝炎已成为主要的输血传播感染风险。从 2 批（A 和 B）经溶剂/去污剂处理的混合血浆中发现的 2 名受血者感染了戊型肝炎病毒（HEV），该病毒确定是由溶剂/去污剂处理的血浆传播的。A 批的 HEV RNA 病毒载量为 433 IU，B 批为 55 IU。回顾性研究发现，100%（13/13）可评估的 A 批受血者和 18%（3/17）可评估的 B 批受血者被 HEV 感染（p<0.001），尽管不一定是在输血时。在可评估的受血者中，86%的输注 HEV RNA 载量>50000 IU 的受血者被感染，最有可能是通过含有 HEV 的溶剂/去污剂处理的血浆，而输注 HEV RNA 载量<50000 IU 的受血者只有 7%（p<0.001）。总的来说，溶剂/去污剂处理的血浆可能携带 HEV。这种情况可能导致输血传播性戊型肝炎的剂量依赖性风险。
