德国 2013 年经输血传播的戊型肝炎。
Transfusion-transmitted hepatitis E in Germany, 2013.
机构信息
Institute for Virology, University Medical Center, Freiburg, Germany.
出版信息
Euro Surveill. 2014 May 29;19(21):20812. doi: 10.2807/1560-7917.es2014.19.21.20812.
The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child.
德国血液捐献者的抗戊型肝炎病毒 (HEV) IgG 血清流行率为 6.8%，而 HEV RNA 的检出率为 0.08%，但缺乏 HEV 传播的明确证据。我们从一名供体中发现了两份血液样本，每份样本的血浆中 HEV RNA 含量分别为 120 IU/ml 和 490 IU/ml。一份含有 7056 IU HEV RNA 的感染剂量通过血小板单采术传播给了一名免疫抑制患者，该患者随后发展为慢性 HEV。此外，一名免疫功能正常的儿童也可能发生了传播。
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