Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Cell Genom. 2024 Mar 13;4(3):100500. doi: 10.1016/j.xgen.2024.100500. Epub 2024 Feb 6.
Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 countries across five continents with extensive demographic, lifestyle, environmental, and clinical information. Whole-genome sequencing is being finalized for over 4,000 cases, with the primary goal of understanding the causes of cancer at eight anatomic sites. Genomic, exposure, and clinical data will be publicly available through the International Cancer Genome Consortium Accelerating Research in Genomic Oncology platform. The Mutographs sample and metadata biorepository constitutes a legacy resource for new projects and collaborations aiming to increase our current research efforts in cancer genomic epidemiology globally.
大型生物库和数据库对于在癌症预防、早期发现、癌症治疗、癌症护理和监测方面取得公平、有效和可持续的进展至关重要。Mutographs 项目创建了一个大型基因组数据集和生物库，其中包含来自五大洲 30 个国家的 7800 多例癌症病例，这些病例具有广泛的人口统计学、生活方式、环境和临床信息。目前正在对 4000 多个病例进行全基因组测序，主要目的是了解八个解剖部位癌症的病因。基因组、暴露和临床数据将通过国际癌症基因组联盟加速肿瘤学研究平台公开提供。Mutographs 样本和元数据生物库是为旨在增加我们在全球癌症基因组流行病学领域当前研究工作的新项目和合作的一项遗产资源。
