Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.
Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland; University of Basel, Biozentrum, CH-4056 Basel, Switzerland.
Curr Opin Struct Biol. 2021 Feb;66:89-95. doi: 10.1016/j.sbi.2020.10.011. Epub 2020 Nov 18.
Centrioles are microtubule-based structures involved in cell division and ciliogenesis. Centriole formation is a highly regulated cellular process and aberrations in centriole structure, size or numbers have implications in multiple human pathologies. In this review, we propose that the proteins that control centriole length can be subdivided into two classes based on their antagonistic activities on centriolar microtubules, which we refer to as 'centriole elongation activators' (CEAs) and 'centriole elongation inhibitors' (CEIs). We discuss and illustrate the structure-function relationship of CEAs and CEIs as well as their interaction networks. Based on our current knowledge, we formulate some outstanding open questions in the field and present possible routes for future studies.
中心体是参与细胞分裂和纤毛发生的微管结构。中心体的形成是一个高度调控的细胞过程，中心体结构、大小或数量的异常与多种人类疾病有关。在这篇综述中，我们提出，控制中心体长度的蛋白质可以根据它们对中心体微管的拮抗活性分为两类，我们称之为“中心体伸长激活剂”（CEAs）和“中心体伸长抑制剂”（CEIs）。我们讨论并说明了 CEAs 和 CEIs 的结构-功能关系及其相互作用网络。基于我们目前的知识，我们提出了该领域的一些悬而未决的问题，并提出了未来研究的可能途径。
