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长骨骨折不愈合:危险因素和手术治疗的文献回顾。

Fracture nonunion in long bones: A literature review of risk factors and surgical management.

机构信息

Specialist Trainee Trauma and Orthopaedic.

Specialist Trainee Trauma and Orthopaedic.

出版信息

Injury. 2021 Jun;52 Suppl 2:S3-S11. doi: 10.1016/j.injury.2020.11.029. Epub 2020 Nov 11.


DOI:10.1016/j.injury.2020.11.029
PMID:33221036
Abstract

Nonunion following a long bone fracture causes considerable morbidity when it occurs. Risk factors depend on specific fractures but there is a complex interplay of injury severity, comorbidities, patient medication and infection. The majority of nonunions occur after long bone fractures with the tibia, femur, forearm, humerus and clavicle predominating. Despite interest in the biological augmentation of fracture healing, the majority of nonunions can be effectively managed with conventional surgical techniques. In this review we present a review of risk factors for nonunion and the outcome following surgical management.

摘要

长骨骨折后发生骨不连会导致相当大的发病率。风险因素取决于特定的骨折,但损伤严重程度、合并症、患者用药和感染之间存在着复杂的相互作用。大多数骨不连发生在长骨骨折后,以胫骨、股骨、前臂、肱骨和锁骨为主。尽管人们对骨折愈合的生物学增强很感兴趣,但大多数骨不连可以通过传统的手术技术有效地治疗。在这篇综述中,我们回顾了骨不连的危险因素和手术治疗后的结果。

相似文献

[1]
Fracture nonunion in long bones: A literature review of risk factors and surgical management.

Injury. 2021-6

[2]
Adolescent clavicle nonunions: potential risk factors and surgical management.

J Shoulder Elbow Surg. 2017-8-24

[3]
Diaphyseal long bone nonunions - types, aetiology, economics, and treatment recommendations.

Int Orthop. 2018-2

[4]
Outcomes of Presumed Aseptic Long-Bone Nonunions With Positive Intraoperative Cultures Through a Single-Stage Surgical Protocol.

J Orthop Trauma. 2018-2

[5]
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Clin Orthop Relat Res. 2005-2

[6]
Treatment of distal clavicle nonunion with and without bone grafting.

Injury. 2018-12

[7]
Long-term outcome following additional rhBMP-7 application in revision surgery of aseptic humeral, femoral, and tibial shaft nonunion.

BMC Musculoskelet Disord. 2017-8-7

[8]
Exchange nailing for nonunion of diaphyseal fractures of the tibia: our results and an analysis of the risk factors for failure.

Bone Joint J. 2016-4

[9]
Retrospective review of 234 scaphoid fractures and nonunions treated with arthroscopy for union and complications.

Scand J Surg. 2008

[10]
Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study.

Musculoskelet Surg. 2015-12

引用本文的文献

[1]
Rewriting the Treatment Paradigm: Ilizarov Method Achieves High Success in Septic Non-Unions Without Local Antibiotics or Biologic Adjuncts.

Biomedicines. 2025-7-8

[2]
Bone Mineral Density and Intermuscular Fat Derived from Computed Tomography Images Using Artificial Intelligence Are Associated with Fracture Healing.

Bioengineering (Basel). 2025-7-19

[3]
Time to consider fracture nonunion an orphan disease? An update into pathophysiology, epidemiology and therapeutic solutions.

Eur J Trauma Emerg Surg. 2025-7-21

[4]
Clinical outcomes of tibial nonunion treatment through the combination of PRP, autogenous iliac bone grafting, and augmentation plating.

Front Surg. 2025-7-3

[5]
Dual locking plate fixation, PRP-augmented autologous bone grafting, and bioactive core construction for femoral fracture nonunion: a retrospective study of 52 cases.

Front Med (Lausanne). 2025-6-12

[6]
Anxiety in trauma patients with nonunion diaphyseal bone fractures.

Int Orthop. 2025-8

[7]
Establishment and validation of an interactive web-based calculator for predicting postoperative functional recovery in metatarsal fracture patients: A LASSO regression model approach.

PLoS One. 2025-6-3

[8]
Bioregenerative autologous scaffold made from bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin to treat non-unions of the femur, humerus, and forearm bones: a case series.

Regen Med. 2025-4

[9]
Successful Treatment of a Nonunion Fracture of the Femur With Extracorporeal Shockwave Therapy: An Evidence-Based Case Report.

Cureus. 2025-5-14

[10]
Effectiveness of the Ilizarov method in treating complex nonunions of the lower limb long bones.

J Int Med Res. 2025-5

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