Saito I, Takeshita E, Saruta T, Nagano S, Sekihara T
Health Center, Keio University, Tokyo, Japan.
Angiology. 1987 Dec;38(12):883-8. doi: 10.1177/000331978703801203.
The possibility that a familial background of hypertension might influence the blood pressure response to a calcium entry blocker was evaluated in 15 normotensive relatives of patients with essential hypertension and 18 normotensive subjects with no family history of hypertension. Under control conditions, blood pressure, heart rate, plasma noradrenaline, adrenaline, and renin activity did not differ between the two groups. Nifedipine, at a dose of 10 mg administered sublingually, lowered the blood pressure and increased the heart rate, plasma noradrenaline, and renin activity. The normotensive relatives of patients with essential hypertension did not differ in their responses from the normotensive subjects with no family history of hypertension, with the exception of plasma noradrenaline thirty minutes after nifedipine. These results provide evidence to suggest that there is no functional abnormality with increased dependency of vascular smooth muscle tone on calcium influx in the prehypertensive state.
在15名原发性高血压患者的血压正常的亲属以及18名无高血压家族史的血压正常受试者中，评估了高血压家族背景可能影响对钙通道阻滞剂血压反应的可能性。在对照条件下，两组之间的血压、心率、血浆去甲肾上腺素、肾上腺素和肾素活性没有差异。舌下含服10 mg剂量的硝苯地平可降低血压，并增加心率、血浆去甲肾上腺素和肾素活性。原发性高血压患者的血压正常亲属与无高血压家族史的血压正常受试者的反应没有差异，但硝苯地平给药30分钟后的血浆去甲肾上腺素除外。这些结果提供了证据表明，在高血压前期状态下，血管平滑肌张力对钙内流的依赖性增加不存在功能异常。
