硝苯地平对正常人和高血压患者血浆肾素活性、血浆肾上腺素及去甲肾上腺素的急性和慢性影响。

Acute and chronic effects of nifedipine on plasma renin activity and plasma adrenaline and noradrenaline in controls and hypertensive patients.

Corea L, Miele N, Bentivoglio M, Boschetti E, Agabiti-Rosei E, Muiesan G

Clin Sci (Lond). 1979 Dec;57 Suppl 5:115s-117s. doi: 10.1042/cs057115s.

Abstract

Nifedipine, a calcium antagonist drug, was given sublingually (10 mg) to seven normal subjects and 19 patients with essential hypertension. In addition, 12 of the hypertensive subjects then received nifedipine (10 mg thrice daily) for 3 weeks. 2. Sublingual administration of nifedipine in hypertensive patients induced a prompt and sustained reduction of blood pressure, without a significant increase of heart rate; in normotensive subjects blood pressure did not change, and heart rate was significantly increased. After chronic treatment, blood pressure remained reduced and heart rate did not rise. 3. Plasma catecholamines and plasma renin activity increased significantly in normotensive subjects after acute administration. 4. After both acute and chronic administration, only plasma noradrenaline was significantly increased in hypertensive patients; in long-term treatment, it was increased in both the lying and standing positions. 5. Nifedipine is an active antihypertensive drug, which may induce some degree of sympathetic activation.

摘要

硝苯地平，一种钙拮抗剂药物，以舌下含服方式给予7名正常受试者和19名原发性高血压患者（10毫克）。此外，12名高血压受试者随后接受硝苯地平（每日三次，每次10毫克）治疗3周。2. 高血压患者舌下含服硝苯地平可使血压迅速且持续降低，心率无显著增加；在血压正常的受试者中，血压未改变，心率显著增加。经过长期治疗后，血压仍降低，心率未升高。3. 急性给药后，血压正常的受试者血浆儿茶酚胺和血浆肾素活性显著增加。4. 急性和长期给药后，高血压患者仅血浆去甲肾上腺素显著增加；在长期治疗中，卧位和立位时均增加。5. 硝苯地平是一种有效的降压药物，可能会引起一定程度的交感神经激活。