Saito I, Takeshita E, Saruta T, Nagano S, Sekihara T
Clin Endocrinol (Oxf). 1986 May;24(5):565-70. doi: 10.1111/j.1365-2265.1986.tb03286.x.
The effects of the calcium entry blocker nifedipine on blood pressure, heart rate, plasma renin activity, aldosterone, noradrenaline and adrenaline were studied in 23 normotensive subjects in the supine and upright positions. Nifedipine, 10 mg administered sublingually, lowered mean blood pressure and increased heart rate, plasma noradrenaline and renin activity without increasing plasma aldosterone in the supine position. The increase in plasma aldosterone in response to upright posture was inhibited by nifedipine, whereas the rise in plasma noradrenaline was augmented. These results suggest that intracellular calcium is important as a regulator of aldosterone secretion as well as of vascular tone in normotensive subjects.
在23名血压正常的受试者处于仰卧位和直立位时，研究了钙通道阻滞剂硝苯地平对血压、心率、血浆肾素活性、醛固酮、去甲肾上腺素和肾上腺素的影响。舌下含服10mg硝苯地平可降低仰卧位时的平均血压，并增加心率、血浆去甲肾上腺素和肾素活性，而不增加血浆醛固酮。硝苯地平可抑制因直立姿势引起的血浆醛固酮升高，而血浆去甲肾上腺素的升高则增强。这些结果表明，细胞内钙作为醛固酮分泌以及血压正常受试者血管张力的调节因子具有重要作用。
