Hicks Evan D, Hameed Muhammad, Shahare Humam, Jones-Brooks Paige, Wong Kevin, Filipek Jacob, Richter Gresham T
Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, USA.
Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
Cureus. 2025 Mar 8;17(3):e80261. doi: 10.7759/cureus.80261. eCollection 2025 Mar.
A three-week-old baby presented with an infantile hemangioma in segmental beard distribution and evidence of PHACES syndrome (posterior fossa abnormalities, hemangiomas, arterial anomalies, cardiac abnormalities, eye anomalies, and sternal defects). Due to the progressive and symptomatic growth of infantile hemangioma, this patient required a multimodal treatment approach, including beta-blocker therapy, intralesional steroid injections, periorbital surgical debulking, airway interventions, and embolization. This report highlights a successful case of a complex PHACES patient that illustrates the significance of phased multidisciplinary care and emphasizes the importance of compliance. A literature review is included to highlight previously reported successful cases using alternative treatments to propranolol monotherapy. This case offers a unique insight into the timeline and outcomes of a PHACES patient with extensive disease requiring a multimodal approach and highlights possible disease presentation in the non-compliant or resistant patient.
一名三周大的婴儿出现节段性胡须分布的婴儿血管瘤，并伴有PHACES综合征（后颅窝异常、血管瘤、动脉异常、心脏异常、眼部异常和胸骨缺损）的迹象。由于婴儿血管瘤进行性生长且出现症状，该患者需要多模式治疗方法，包括β受体阻滞剂治疗、瘤内类固醇注射、眶周手术减容、气道干预和栓塞。本报告重点介绍了一例复杂PHACES患者的成功病例，阐明了分阶段多学科护理的重要性，并强调了依从性的重要性。还纳入了文献综述，以突出先前报道的使用普萘洛尔单一疗法替代治疗的成功病例。该病例为深入了解一名患有广泛疾病、需要多模式治疗方法的PHACES患者的病程和结局提供了独特视角，并突出了不依从或耐药患者可能出现的疾病表现。
