Traditional Persian Medicine, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, No. 8 Shams Alley, Vali-e-Asr Street, Tehran, 1516745811, Iran; Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, No.146, South Gandi Ave, Vanak Sq, Tehran, 1517964311, Iran; Integrative Oncology Research Group, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, No.146, South Gandi Ave, Vanak Sq, Tehran, 1517964311, Iran.
Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, No.146, South Gandi Ave, Vanak Sq, Tehran, 1517964311, Iran; Medical Students Research Committee, Shahed University College of Medicine, Mostafa Khomeini Hospital, Italy Street, Keshavarz Blvd, Tehran, Iran.
Complement Ther Med. 2020 Dec;55:102615. doi: 10.1016/j.ctim.2020.102615. Epub 2020 Nov 9.
Herbs have been reported to be effective in reducing lymphedema burden. This paper aimed to review literature reporting on herbs for lymphedema treatment.
A systematic review was performed using the PRISMA guideline. Clinical studies on herbal intervention and lymphedema were included. Evidence on the effectiveness of herbal interventions for desired outcomes including reduction of edema volume, other symptoms, quality of life and inflammation were collected and assessed in detail.
In all twenty studies were included in this review. Of these 14 studies were randomized clinical trials and the rest were prospective pilot studies. Herbal treatment was reported for breast cancer-related lymphedema in most studies and coumarin was the most reported herb that used for lymphedema management. Edema volume reduction (17 out of 20) and symptoms improvement (15 out of 20) were the outcomes reported in most studies.
Phytochemicals can be a promising pharmacotherapy for lymphedema management. However, further evidence is needed to establish definite effectiveness for the use of herbal remedies for lymphedema management.
据报道，草药在减轻淋巴水肿负担方面具有一定效果。本文旨在对治疗淋巴水肿的草药文献进行综述。
采用 PRISMA 指南进行系统综述。纳入了关于草药干预与淋巴水肿的临床研究。详细收集并评估了关于草药干预对期望结果（包括水肿体积减少、其他症状、生活质量和炎症）的有效性的证据。
本综述共纳入 20 项研究。其中 14 项为随机临床试验，其余为前瞻性试点研究。大多数研究报告了草药治疗乳腺癌相关淋巴水肿，香豆素是用于淋巴水肿管理的最常报告的草药。大多数研究报告了水肿体积减少（20 项中的 17 项）和症状改善（20 项中的 15 项）。
植物化学物质可能是淋巴水肿管理有前景的药物治疗方法。然而，需要进一步的证据来确定草药疗法在淋巴水肿管理中的有效性。
