Rastogi Subha, Pandey Madan Mohan, Rawat A K S
Pharmacognosy & Ethnopharmacology Division, CSIR- National Botanical Research Institute, Lucknow 226 001, India.
Pharmacognosy & Ethnopharmacology Division, CSIR- National Botanical Research Institute, Lucknow 226 001, India.
Phytomedicine. 2016 Oct 15;23(11):1082-9. doi: 10.1016/j.phymed.2015.10.012. Epub 2015 Nov 10.
Medicinal plants have been used in patients with congestive heart failure, systolic hypertension, angina pectoris, atherosclerosis, cerebral insufficiency, venous insufficiency and arrhythmia since centuries. A recent increase in the popularity of alternative medicine and natural products has revived interest in traditional remedies that have been used for the treatment of cardiovascular diseases.
The purpose of this review is to provide updated, comprehensive and categorized information on the history and traditional uses of some herbal medicines that affect the cardiovascular system in order to explore their therapeutic potential and evaluate future research opportunities.
Systematic literature searches were carried out and the available information on various medicinal plants traditionally used for cardiovascular disorders was collected via electronic search (using Pubmed, SciFinder, Scirus, GoogleScholar, JCCC@INSTIRC and Web of Science) and a library search for articles published in peer-reviewed journals. No restrictions regarding the language of publication were imposed.
This article highlights the cardiovascular effects of four potent traditional botanicals viz. Garlic (Allium sativum), Guggul (Commiphora wightii), Hawthorn (Crataegus oxyacantha) and Arjuna (Terminalia arjuna). Although these plants have been used in the treatment of heart disease for hundreds of years, current research methods show us they can be utilized effectively in the treatment of cardiovascular diseases including ischemic heart disease, congestive heart failure, arrhythmias and hypertension.
Although the mechanisms of action are not very clear, there is enough evidence of their efficacy in various cardiovascular disorders. However, for bringing more objectivity and also to confirm traditional claims, more systematic, well-designed animal and randomized clinical studies with sufficient sample sizes are necessary. Multidisciplinary research is still required to exploit the vast potential of these plants. Potential synergistic and adverse side effects of herb-drug interactions also need to be studied. These approaches will help in establishing them as remedies for cardiovascular diseases and including them in the mainstream of healthcare system.
几个世纪以来，药用植物一直被用于治疗充血性心力衰竭、收缩期高血压、心绞痛、动脉粥样硬化、脑供血不足、静脉功能不全和心律失常患者。近年来，替代医学和天然产品的 popularity 有所增加，这重新唤起了人们对用于治疗心血管疾病的传统疗法的兴趣。
本综述的目的是提供有关一些影响心血管系统的草药的历史和传统用途的最新、全面且分类的信息，以探索其治疗潜力并评估未来的研究机会。
进行了系统的文献检索，并通过电子检索（使用 Pubmed、SciFinder、Scirus、GoogleScholar、JCCC@INSTIRC 和 Web of Science）以及在图书馆搜索同行评审期刊上发表的文章，收集了有关传统上用于心血管疾病的各种药用植物的可用信息。对出版物的语言没有限制。
本文重点介绍了四种有效的传统植物药的心血管作用，即大蒜（Allium sativum）、古古勒（Commiphora wightii）、山楂（Crataegus oxyacantha）和阿朱那（Terminalia arjuna）。尽管这些植物已被用于治疗心脏病数百年，但目前的研究方法表明，它们可有效用于治疗包括缺血性心脏病、充血性心力衰竭、心律失常和高血压在内的心血管疾病。
虽然作用机制尚不完全清楚，但有足够的证据表明它们在各种心血管疾病中具有疗效。然而，为了提高客观性并证实传统说法，需要进行更系统、设计良好且样本量充足的动物和随机临床研究。仍需要多学科研究来挖掘这些植物的巨大潜力。草药与药物相互作用的潜在协同和不良反应也需要研究。这些方法将有助于将它们确立为心血管疾病的治疗方法，并将它们纳入医疗保健系统的主流。
