Nutrition and Clinical Services Division (NCSD), 56291International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh.
Department of Global Health, University of Washington, Seattle, WA, USA.
Food Nutr Bull. 2021 Mar;42(1):23-35. doi: 10.1177/0379572120973908. Epub 2020 Nov 23.
The changes of plasma retinol binding protein 4 (RBP4) level after a nutrition intervention can indicate the metabolic changes associated with the delivered intervention.
We investigated the changes in plasma RBP4 level among 12- to 18-month-old children after a nutrition intervention and measured its association with subcutaneous adiposity, maternal characteristics, and inflammation.
Data of 520 undernourished children (250 of them had length-for-age score [LAZ] <-1 to -2 and 270 had LAZ score <-2) were collected from the Bangladesh Environmental Enteric Dysfunction study conducted in Dhaka, Bangladesh. Multivariable linear regression and generalized estimation equations (GEE) modeling techniques were used to measure the association.
At baseline, median RBP4 level was 19.9 mg/L (interquartile range [IQR]: 7.96), and at the end of the intervention, it was 20.6 mg/L (IQR: 9.06). Percentage changes in plasma RBP4 level were not significantly associated ( > .05) with the percentage changes in child's height, weight, and subcutaneous adiposity. But maternal height (regression coefficient, β = -1.62, = .002) and milk intake (β = -0.05, = .01) were negatively and maternal weight was positively associated (β = 0.56, = .03) with the changes in RBP4 levels. The GEE models revealed negative association of RBP4 levels with C-reactive protein (CRP; β = -0.14, < .05) and α-1-acid glycoprotein (AGP; β = -0.03, < .05).
Children whose mothers were taller experienced less increase in plasma RBP4 level, and children whose mothers had a higher weight experienced more increase in the RBP4 level from baseline. We have also found that CRP and AGP levels and intake of whole milk were negatively associated with the plasma RBP4 level.
营养干预后血浆视黄醇结合蛋白 4（RBP4）水平的变化可以反映与所提供干预相关的代谢变化。
我们研究了营养干预后 12 至 18 个月大的儿童血浆 RBP4 水平的变化，并测量了其与皮下脂肪、产妇特征和炎症的关系。
本研究数据来自孟加拉国达卡开展的孟加拉环境肠内功能障碍研究，共纳入 520 名营养不良儿童（250 名儿童的年龄别身长分数[LAZ]<-1 至-2，270 名儿童的 LAZ 评分<-2）。采用多变量线性回归和广义估计方程（GEE）模型技术来测量相关性。
在基线时，RBP4 中位数为 19.9mg/L（IQR：7.96），在干预结束时为 20.6mg/L（IQR：9.06）。血浆 RBP4 水平的百分比变化与儿童身高、体重和皮下脂肪的百分比变化无显著相关性（>.05）。然而，母亲身高（回归系数，β=-1.62， =.002）和牛奶摄入量（β=-0.05， =.01）与 RBP4 水平的变化呈负相关，而母亲体重与 RBP4 水平的变化呈正相关（β=0.56， =.03）。GEE 模型显示 RBP4 水平与 C 反应蛋白（CRP；β=-0.14， <.05）和α-1-酸性糖蛋白（AGP；β=-0.03， <.05）呈负相关。
母亲较高的儿童血浆 RBP4 水平增加较少，而母亲体重较高的儿童从基线开始 RBP4 水平增加较多。我们还发现 CRP 和 AGP 水平以及全脂牛奶的摄入量与血浆 RBP4 水平呈负相关。
