Department of Science & Technology (DST)- Centre for Policy Research, Indian Institute of Science (IISc), Bengaluru, India.
Department of Biotechnology, Himachal Pradesh University, Shimla, India.
CNS Neurol Disord Drug Targets. 2021;20(2):101-104. doi: 10.2174/1871527319666201120143654.
COVID-19 is one of the most disastrous respiratory diseases (after the 1918 influenza outbreak) spreading in the community. So far, it has killed 7,37,417 individuals. High variability in the viral genome and its greater ability to spread in the human community are badly affecting the comorbid individuals. Although infected individuals mainly possess respiratory issues, neurological manifestations in these individuals cannot be overlooked. The literature search is based on the recent development in the concerned field. We searched databases like PubMed, Google Scholar, and ScienceDirect using the keywords "COVID-19", "neurological manifestations", "CNS", and "PNS". The major neurological complications observed in these patients are encephalitis, necrotising haemorrhagic encephalopathy, Guillain-Barré Syndrome, smell/taste impairment, epileptic seizures, and abnormal states of consciousness. COVID-19 infection is just more than a cough, fever, and respiratory illness; it can cause indirect neurological complications in infected patients. It is therefore advised to treat and have a careful observation of the COVID-19 patients for neurological manifestations.
COVID-19 是一种在社区中传播的极具破坏性的呼吸系统疾病（仅次于 1918 年流感大爆发）。到目前为止，它已经导致 737417 人死亡。病毒基因组的高度变异性及其在人类社区中更大的传播能力，严重影响了合并症患者。尽管感染个体主要存在呼吸系统问题，但不能忽视这些个体的神经表现。文献检索基于该领域的最新发展。我们使用“COVID-19”、“神经表现”、“中枢神经系统”和“周围神经系统”等关键词在 PubMed、Google Scholar 和 ScienceDirect 等数据库中进行了搜索。在这些患者中观察到的主要神经并发症包括脑炎、坏死性出血性脑病、吉兰-巴雷综合征、嗅觉/味觉障碍、癫痫发作和意识异常。COVID-19 感染不仅仅是咳嗽、发烧和呼吸道疾病；它会在感染患者中引起间接的神经并发症。因此，建议对 COVID-19 患者进行治疗并密切观察其神经表现。
