Masrur Amena, Adnan Muhammad, Khan Furqan Ahmed, Tayyab Ali
Department of Ophthalmology, Islamabad Medical and Dental College, Islamabad, Pakistan.
J Coll Physicians Surg Pak. 2020 Nov;30(11):1166-1169. doi: 10.29271/jcpsp.2020.11.1166.
To investigate the association between skin prick test and severity of allergic conjunctivitis.
Cross sectional observational study. Study Place and Duration of Study: Akbar Niazi Teaching Hospital, Bara Kahu, Islamabad, between March and September 2019.
150 eyes of 150 diagnosed cases of allergic conjunctivitis, who had had a skin prick test, were included in the study. Cases with other concurrent ocular surface diseases, conjunctivitides, systemic allergies, and those on systemic steroids, anti-histamines and tricyclic antidepressant agents were excluded. Signs of allergic conjunctivitis were graded via slit-lamp examination using a 5-5-5 exacerbation grading scale. Allergic conjunctivitis was classified as being severe if the total score was ≥230, moderate if the score was >20 and <230, and mild if the score was ≤20. Frequency distribution was reported for age, gender and result of skin prick test. Test of significance and correlation analysis was carried out between the result of skin prick test and the severity of allergic conjunctivitis using Statistical Package for Social Sciences version 20.0. A p-value of <0.05 was taken as significant.
Mean age was 18.62 (±8.15) years in 91 males and 59 females. Mild (n = 28), moderate (n = 77), and severe (n = 45) cases showed no statistically significant correlation with the skin prick test (positive or negative) in any of the three categories (mild p = 0.44, r = 0.153, moderate p = 0.89, r = 0.016, and severe p = 0.73, r = 0.052).
Skin prick test did not show a significant association or correlation with the severity of allergic conjunctivitis. Key Words: Allergic conjunctivitis, Hypersensitivity, Skin prick test.
探讨皮肤点刺试验与过敏性结膜炎严重程度之间的关联。
横断面观察性研究。研究地点及研究时长：2019年3月至9月期间，位于伊斯兰堡巴拉卡胡的阿克巴·尼亚齐教学医院。
本研究纳入150例已确诊过敏性结膜炎且进行过皮肤点刺试验的患者的150只眼。排除患有其他并发眼表疾病、结膜炎、全身性过敏的病例，以及正在使用全身性类固醇、抗组胺药和三环类抗抑郁药的患者。通过裂隙灯检查，使用5 - 5 - 5加重分级量表对过敏性结膜炎的体征进行分级。如果总分≥230，则过敏性结膜炎被分类为重度；如果分数>20且<230，则为中度；如果分数≤20，则为轻度。报告了年龄、性别和皮肤点刺试验结果的频率分布。使用社会科学统计软件包20.0对皮肤点刺试验结果与过敏性结膜炎严重程度之间进行显著性检验和相关性分析。p值<0.05被视为具有显著性。
91例男性和59例女性的平均年龄为18.62（±8.15）岁。轻度（n = 28）、中度（n = 77）和重度（n = 45）病例在三个类别中的任何一个类别（轻度p = 0.44，r = 0.153；中度p = 0.89，r = 0.016；重度p = 0.73，r = 0.052）中与皮肤点刺试验（阳性或阴性）均无统计学显著相关性。
皮肤点刺试验与过敏性结膜炎的严重程度未显示出显著关联或相关性。关键词：过敏性结膜炎、超敏反应、皮肤点刺试验。
